Sharma Namita, Ahmad Ayesha, Bhat Gull M, Aziz Sheikh A, Lone Mohammad Maqbool, Bhat Nisar A
Department of Medical Oncology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
Department of Paediatrics, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Indian J Med Paediatr Oncol. 2017 Oct-Dec;38(4):471-477. doi: 10.4103/ijmpo.ijmpo_95_16.
The purpose of this retroprospective study was to study the epidemiological characteristics and outcomes of children with solid tumors at our institution.
Three hundred and three pediatrics patients registered at Regional Cancer Centre (RCC), Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Kashmir, between January 2008 and June 2014, were analyzed with regard to demographic status, presenting complaints, investigations, treatment, morbidity, and outcomes. Standard statistical methods were used for analysis.
Among 19,880 patients registered at RCC, SKIMS from January 2008 till June 2014, 986 (4.9%) were of pediatric age group. Of these, 303 (30.7%) patients had pediatric solid tumors. The male-to-female ratio was 1.04, there were no infants (up to 27 days), 6% were infants and toddlers (28 days-23 months), 39% were children (2-11 years), and 55% were adolescents (12-19 years). There were 86% rural patients and 14% urban patients. Most common were central nervous system tumors (25.74%), followed by germ cell tumors (14.52%), primitive neuroectodermal tumor/Ewing sarcoma (13.86%), Wilms' tumor (8.9%), osteosarcoma (6.6%), rhabdomyosarcoma (5.6%), colorectal cancer (5.28%), neuroblastoma (4.9%), and retinoblastoma (2.6%). Outcomes: 33.9% patients went into remission, 35.64% were defaulters, 2.97% had stable disease, 2.31% had partial response, 20.79% expired, and 3.96% were still on treatment. Of all these patients, 5.28% had a relapse.
Across the series, advanced stage of presentation, a high incidence of default and poor follow-up was seen. Multiple interrelated factors are responsible for the poorer outlook of childhood cancer in Kashmir.
本回顾性研究旨在探讨我院实体瘤患儿的流行病学特征及治疗结果。
对2008年1月至2014年6月期间在克什米尔斯利那加谢里 - 克什米尔医学科学研究所区域癌症中心（RCC）登记的303例儿科患者的人口统计学状况、就诊主诉、检查、治疗、发病率及治疗结果进行分析。采用标准统计学方法进行分析。
在2008年1月至2014年6月期间在RCC、SKIMS登记的19880例患者中，986例（4.9%）为儿童年龄组。其中，303例（30.7%）患者患有儿童实体瘤。男女比例为1.04，无婴儿（27天及以内），6%为婴幼儿（28天至23个月），39%为儿童（2至11岁），55%为青少年（12至19岁）。农村患者占86%，城市患者占14%。最常见的是中枢神经系统肿瘤（25.74%），其次是生殖细胞肿瘤（14.52%）、原始神经外胚层肿瘤/尤文肉瘤（13.86%）、肾母细胞瘤（8.9%）、骨肉瘤（6.6%）、横纹肌肉瘤（5.6%）、结直肠癌（5.28%）、神经母细胞瘤（4.9%）和视网膜母细胞瘤（2.6%）。治疗结果：33.9%的患者病情缓解，35.64%的患者失访，2.97%的患者病情稳定，2.31%的患者部分缓解，20.79%的患者死亡，3.96%的患者仍在接受治疗。在所有这些患者中，5.28%的患者复发。
在整个系列研究中，发现患者就诊时处于晚期、失访率高且随访情况不佳。多种相互关联的因素导致克什米尔儿童癌症的预后较差。
