Vezakis Antonios, Polydorou Andreas, Kontis Elissaios, Pantiora Eirini, Papanikolaou Ioannis S, Fragulidis Georgios
2 Department of Surgery and Endoscopy Unit, National and Kapodistrian University of Athens, Aretaieion Hospital, Athens, Greece (Antonios Vezakis, Andreas Polydorou, Eirini Pantiora, Ioannis S. Papanikolaou, Georgios Fragulidis).
Institute of Liver Studies, King's College Hospital, Denmark Hill, London, UK (Elissaios Kontis).
Ann Gastroenterol. 2018 Jan-Feb;31(1):109-114. doi: 10.20524/aog.2017.0206. Epub 2017 Oct 26.
The aim of the study was to evaluate the safety and efficacy of extending a previous endoscopic sphincterotomy (ES) in patients with retained or recurrent common bile duct (CBD) stones.
Between 2001 and 2013, extension of a previous ES, for known or suspected CBD stones, was performed in 118 patients (m/f, 53/65) with a median age of 74 (range: 31-91) years (group A). During the same period, ES was performed in 1064 patients with suspected or known choledocholithiasis (group B). The efficacy and complications of the extension (group A) were analyzed and a comparison was made between groups regarding complications.
Bile duct cannulation was straightforward in all patients in group A, while it was considered difficult in 49% of patients in group B. Complete clearance was achieved in 76/97 patients (78%) with CBD stones, after a mean of 1.18 attempts per patient. Mechanical lithotripsy was required in 10% of patients. After extension, immediate bleeding occurred in 24 patients (20%), which stopped spontaneously in 9 (37%) and endoscopic hemostasis was required in the remainder. Complications were more frequent in group B (5.3% vs. 0.8%, P=0.031), but there was no significant difference for any individual complication. Immediate bleeding was more common in group B (29% vs. 20%, P=0.035), but there was no difference in clinical bleeding.
Extension of a previous ES seems to be a simple, effective and safe technique, allowing stone clearance in nearly 80% of patients; it is thus recommended in patients with CBD stones after ES.
本研究的目的是评估对既往有胆总管(CBD)结石残留或复发患者进行内镜括约肌切开术(ES)延长术的安全性和有效性。
2001年至2013年期间,对118例(男/女,53/65)已知或疑似CBD结石患者进行了既往ES延长术,患者中位年龄74岁(范围:31 - 91岁)(A组)。同期,对1064例疑似或已知胆总管结石患者进行了ES(B组)。分析了延长术(A组)的有效性和并发症,并比较了两组之间的并发症情况。
A组所有患者胆管插管均顺利,而B组49%的患者被认为插管困难。97例CBD结石患者中,76例(78%)在平均每位患者进行1.18次尝试后结石完全清除。10%的患者需要进行机械碎石术。延长术后,24例患者(20%)立即发生出血,其中9例(37%)自行停止,其余患者需要内镜止血。B组并发症更常见(5.3%对0.8%,P = 0.031),但任何个体并发症均无显著差异。B组立即出血更常见(29%对20%,P = 0.035),但临床出血无差异。
既往ES延长术似乎是一种简单、有效且安全的技术,可使近80%的患者结石清除;因此,推荐用于ES术后有CBD结石的患者。