Faculty of Pharmacy, Osaka Ohtani University.
Gifu Pharmaceutical University.
Int J Med Sci. 2018 Jan 1;15(2):101-107. doi: 10.7150/ijms.22206. eCollection 2018.
Ultraviolet irradiation is effectively used as a disinfection method for inactivating microorganisms. We investigated the bactericidal effects by irradiation with a deep-ultraviolet light-emitting diode (DUV-LED) on the causative microorganisms of catheter related blood stream infection contaminating the solution for intravenous infusion. For irradiation, prototype modules for water disinfection with a DUV-LED were used. Experiments were conducted on five kinds of microorganisms. We examined the dependence of bactericidal action on eleven solutions. Administration sets were carried out three types. When the administration set JY-PB343L containing the infusion tube made of polybutadiene was used, the bactericidal action of the DUV-LED against all tested microorganisms in the physiological saline solutions was considered to be effective. We confirmed that the number of viable bacteria decreased in 5% glucose solution and electrolyte infusions with DUV-LED irradiation. These results indicate that the DUV-LED irradiation has bactericidal effects in glucose infusion and electrolyte infusions by irradiating via a plasticizer-free polybutadiene administration set. We consider DUV-LED irradiation to be clinically applicable.
紫外线照射被有效地用作一种消毒方法，用于灭活微生物。我们研究了深紫外线发光二极管（DUV-LED）照射对污染静脉输液溶液的导管相关血流感染病原体的杀菌效果。对于照射，使用了具有 DUV-LED 的水消毒原型模块。在五种微生物上进行了实验。我们检查了十一种溶液对杀菌作用的依赖性。进行了三种类型的输液套件实验。当使用含有聚丁二烯制成的输液管的 JY-PB343L 输液套件时，DUV-LED 对生理盐水溶液中所有测试微生物的杀菌作用被认为是有效的。我们确认，DUV-LED 照射可减少 5%葡萄糖溶液和电解质输注中的活菌数。这些结果表明，通过无增塑剂的聚丁二烯输液套件照射，DUV-LED 照射对葡萄糖输注和电解质输注具有杀菌作用。我们认为 DUV-LED 照射在临床上是可行的。
