Orygen, the National Centre of Excellence in Youth Mental Health, Locked Bag 10, 35 Poplar Road, Parkville, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Locked Bag 10, Parkville, Melbourne, VIC 3052, Australia; Melbourne School of Psychological Sciences, University of Melbourne, Level 12, Redmond Barry Building 115, Parkville, Melbourne, VIC 3010, Australia.
Orygen, the National Centre of Excellence in Youth Mental Health, Locked Bag 10, 35 Poplar Road, Parkville, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Locked Bag 10, Parkville, Melbourne, VIC 3052, Australia.
J Affect Disord. 2018 Mar 15;229:498-505. doi: 10.1016/j.jad.2017.12.088. Epub 2018 Jan 3.
Both major depressive disorder (MDD) and first episode schizophrenia spectrum (FES) are associated with significant neurocognitive deficits. However, it remains unclear whether the neurocognitive deficits in individuals with FES are more severe if there is comorbid depressive disorder. The aim of this study was to compare the neurocognitive profiles between those with and without full-threshold depressive disorder in FES.
This study involved secondary analysis of baseline data from a randomized controlled trial of vocational intervention for young people with first-episode psychosis (N = 82; age range: 15-25 years).
Those with full-threshold depressive disorder (n = 24) had significantly better information processing speed than those without full-threshold depressive disorder. Severity of depressive symptoms was also associated with better information processing speed.
In additional to the cross-sectional design, limitations of this study include the absence of assessing insight as a potential mediator.
After the first psychotic episode, it could be speculated that those with better information processing speed may be more likely to develop full-threshold depressive disorder, as their ability to efficiently process information may allow them to be more aware of their situations and environments, and consequently to have greater insight into the devastating consequences of FES. Such novel findings support the examination of full-threshold depressive disorder in relation to neurocognitive performance across illness phases in future work.
重度抑郁症（MDD）和首发精神分裂症谱系（FES）均与明显的神经认知缺陷有关。然而，如果首发精神分裂症谱系患者合并有抑郁障碍，其神经认知缺陷是否更严重仍不清楚。本研究的目的是比较 FES 中伴有和不伴有全阈值抑郁障碍的个体的神经认知特征。
本研究对一项针对首发精神病青年职业干预的随机对照试验（N = 82；年龄范围：15-25 岁）的基线数据进行了二次分析。
伴有全阈值抑郁障碍（n = 24）的个体的信息处理速度明显优于不伴有全阈值抑郁障碍的个体。抑郁症状的严重程度也与更好的信息处理速度相关。
除了横断面设计之外，本研究还存在一些局限性，包括没有评估洞察力作为潜在的中介因素。
在首发精神病后，可以推测那些信息处理速度较好的个体可能更有可能发展为全阈值抑郁障碍，因为他们高效处理信息的能力可能使他们更能意识到自己的情况和环境，从而对首发精神分裂症谱系的破坏性后果有更深刻的认识。这些新的发现支持在未来的工作中检查全阈值抑郁障碍与疾病各阶段的神经认知表现之间的关系。
