Nowicki M J, Tong M J, Bohman R E
J Infect Dis. 1985 Dec;152(6):1245-8. doi: 10.1093/infdis/152.6.1245.
The phenotypic characteristics of peripheral blood lymphocytes (PBLs) from responders and nonresponders to hepatitis B (HB) vaccine and their response to pokeweed mitogen (PWM) stimulation in vitro were compared. The nonresponders had significantly higher absolute numbers and percentages of T11+, HNK-1+, and T8+ lymphocytes. Also, after PWM stimulation, PBLs from HB-vaccine nonresponders had impaired IgG and IgM production and failed to produce antibodies to HB surface antigen in vitro. These findings suggest that healthy individuals who fail to produce such antibodies have a higher population of suppressor lymphocytes that alters their normal immune response to HB vaccination.
比较了对乙型肝炎（HB）疫苗有反应者和无反应者外周血淋巴细胞（PBL）的表型特征及其在体外对商陆有丝分裂原（PWM）刺激的反应。无反应者的T11 +、HNK - 1 +和T8 +淋巴细胞的绝对数量和百分比显著更高。此外，经PWM刺激后，HB疫苗无反应者的PBL产生IgG和IgM的能力受损，且在体外不能产生针对HB表面抗原的抗体。这些发现表明，无法产生此类抗体的健康个体具有较高数量的抑制性淋巴细胞，这改变了他们对HB疫苗接种的正常免疫反应。
