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埃塞俄比亚西北部德布雷塔博尔结核病治疗效果不佳的相关因素。

Factors associated with poor treatment outcome of tuberculosis in Debre Tabor, northwest Ethiopia.

作者信息

Melese Addisu, Zeleke Balew

机构信息

Department of Medical Laboratory Science, College of Health Sciences, Debre Tabor University, P.O.BOX 272, Debre Tabor, Ethiopia.

Department of Nursing, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.

出版信息

BMC Res Notes. 2018 Jan 15;11(1):25. doi: 10.1186/s13104-018-3129-8.

Abstract

OBJECTIVE

Directly observed treatment short course has been implemented as part of the national tuberculosis control program in Ethiopia. The strategy, as evidenced by different studies, has improved the survival and treatment success rate of tuberculosis patients. However, some patients failed to complete their treatments and the factors for this failure were not assessed in the study area. We, therefore sought to identify factors associated with poor treatment outcome of tuberculosis in Debre Tabor, northwest Ethiopia.

RESULTS

We included 303 patients (173 males, 130 females) with mean age of 34.9 years in the study and 39 (12.9%) patients were with poor treatment outcome over the period of 5 years (2008-2013). Being male, urban residency, positive and unknown smear result at the 2nd month of treatment and patients in the age of 35-44 years were more likely to have poor treatment outcomes than their counterparts. Patients in the new treatment category were less likely to have poor treatment outcome compared to the retreated cases. Further studies are recommended to explore the association of poor treatment outcome with other important factors which are not investigated by this study.

摘要

目的

在埃塞俄比亚,直接观察短程治疗已作为国家结核病控制项目的一部分得以实施。不同研究表明,该策略提高了结核病患者的生存率和治疗成功率。然而,一些患者未能完成治疗,且研究地区未对治疗失败的因素进行评估。因此,我们试图确定埃塞俄比亚西北部德布雷塔博尔结核病治疗效果不佳的相关因素。

结果

我们纳入了303例患者(173例男性,130例女性),研究对象的平均年龄为34.9岁,在5年期间(2008 - 2013年)有39例(12.9%)患者治疗效果不佳。男性、城市居民、治疗第2个月时涂片结果为阳性及结果未知的患者以及年龄在35 - 44岁的患者比其他患者更有可能出现治疗效果不佳的情况。与复治病例相比,新治疗组的患者治疗效果不佳的可能性较小。建议进一步开展研究,以探讨治疗效果不佳与本研究未调查的其他重要因素之间的关联。

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