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[早产儿支气管肺发育不良药物治疗的研究进展]

[Research progress in drug therapy for bronchopulmonary dysplasia in preterm infants].

作者信息

Yang Yu-Chen, Mao Jian, Li Juan

机构信息

Department of Neonatology, Shengjing Hospital of China Medical University, Shenyang 110004, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2018 Jan;20(1):67-71. doi: 10.7499/j.issn.1008-8830.2018.01.014.

DOI:10.7499/j.issn.1008-8830.2018.01.014
PMID:29335086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7390319/
Abstract

Bronchopulmonary dysplasia (BPD) is the most common long-term complication in surviving extremely preterm infants. This may lead to pulmonary hypertension, increase late neonatal mortality, and cause abnormal neural development. There is still controversy over the efficacy, as well as advantages and disadvantages, of drug therapy for BPD in preterm infants. This article reviews the research progress in the drug therapy for BPD.

摘要

支气管肺发育不良(BPD)是存活的极早产儿最常见的长期并发症。这可能导致肺动脉高压,增加新生儿晚期死亡率,并引起神经发育异常。关于早产儿BPD药物治疗的疗效以及利弊仍存在争议。本文综述了BPD药物治疗的研究进展。

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本文引用的文献

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Inhaled and systemic steroid exposure and neurodevelopmental outcome of preterm neonates.早产儿吸入和全身使用类固醇激素与神经发育结局
J Matern Fetal Neonatal Med. 2018 Oct;31(20):2665-2672. doi: 10.1080/14767058.2017.1350644. Epub 2017 Jul 16.
2
Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia.支气管肺发育不良患儿肺动脉高压的评估与管理
J Pediatr. 2017 Sep;188:24-34.e1. doi: 10.1016/j.jpeds.2017.05.029. Epub 2017 Jun 20.
3
Association Between Early Low-Dose Hydrocortisone Therapy in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years of Age.极早产儿生后早期接受低剂量氢化可的松治疗与 2 岁时神经发育结局的关系。
JAMA. 2017 Apr 4;317(13):1329-1337. doi: 10.1001/jama.2017.2692.
4
Caffeine modulates glucocorticoid-induced expression of CTGF in lung epithelial cells and fibroblasts.咖啡因调节糖皮质激素诱导的肺上皮细胞和成纤维细胞中结缔组织生长因子的表达。
Respir Res. 2017 Mar 23;18(1):51. doi: 10.1186/s12931-017-0535-8.
5
[Clinical efficacy of pulmonary surfactant combined with budesonide for preventing bronchopulmonary dysplasia in very low birth weight infants].肺表面活性物质联合布地奈德预防极低出生体重儿支气管肺发育不良的临床疗效
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Feb;19(2):137-141. doi: 10.7499/j.issn.1008-8830.2017.02.002.
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Pediatr Pulmonol. 2017 Jul;52(7):968-975. doi: 10.1002/ppul.23680. Epub 2017 Feb 6.
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Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants.用于预防早产儿支气管肺发育不良的全身皮质类固醇治疗方案。
Cochrane Database Syst Rev. 2017 Jan 31;1(1):CD010941. doi: 10.1002/14651858.CD010941.pub2.
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Inhaled Corticosteroids for Bronchopulmonary Dysplasia: A Meta-analysis.吸入性皮质类固醇用于支气管肺发育不良:一项荟萃分析。
Pediatrics. 2016 Dec;138(6). doi: 10.1542/peds.2016-2511.
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Cochrane Database Syst Rev. 2016 Aug 22;2016(8):CD000501. doi: 10.1002/14651858.CD000501.pub4.
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