Deakin University, Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Geelong, Australia.
Department of Radiology, The Ottawa Hospital, University of Ottawa, Ottawa, Canada.
J Bone Miner Res. 2018 Apr;33(4):651-657. doi: 10.1002/jbmr.3357. Epub 2018 Jan 16.
Marrow adipose tissue (MAT) accumulation with normal aging impacts the bone, hemopoiesis, and metabolic pathways. We investigated whether exercise was associated with lower MAT, as measured by vertebral marrow fat fraction (VFF) on magnetic resonance imaging. A total of 101 healthy individuals (54 females) aged 25 to 35 years without spine or bone disease but with distinct exercise histories were studied. Long-distance runners (67 km/wk, n = 25) exhibited lower mean lumbar VFF (27.9% [8.6%] versus 33.5% [6.0%]; p = 0.0048) than non-sporting referents (n = 24). In habitual joggers (28 km/wk, n = 30), mean lumbar VFF was 31.3% (9.0%) (p = 0.22 versus referents) and 6.0 percentage points lower than referents at vertebrae T , T , and T (p ≤ 0.023). High-volume road cycling (275 km/wk, n = 22) did not impact VFF. 3D accelerations corresponding to faster walking, slow jogging, and high-impact activities correlated with lower VFF, whereas low-impact activities and sedentary time correlated with higher mean lumbar VFF (all p ≤ 0.05). Given an estimated adipose bone marrow conversion of 7% per decade of life, long distance runners, with 5.6 percentage points lower VFF, showed an estimated 8-year younger vertebral marrow adipose tissue phenotype. Regression analysis showed a 0.7 percentage point reduction in mean lumbar VFF with every 9.4 km/wk run (p = 0.002). This study presents the first evidence in humans or animals that specific volumes and types of exercise may influence the age-determined adipose marrow conversion and result in low MAT. These results identify a potentially modifiable risk factor for prevalent chronic conditions related to bone metabolism, hemopoietic production, and other metabolic functions with potential global health applications. © 2017 American Society for Bone and Mineral Research.
骨髓脂肪组织（MAT）随正常衰老而积累，影响骨骼、造血和代谢途径。我们研究了运动是否与磁共振成像（MRI）测量的椎体骨髓脂肪分数（VFF）较低有关。研究共纳入 101 名年龄在 25 至 35 岁、无脊柱或骨骼疾病但运动史不同的健康个体（女性 54 名）。长距离跑步者（每周 67 公里，n=25）的平均腰椎 VFF 为 27.9%（8.6%），明显低于非运动参照者（n=24）的 33.5%（6.0%）（p=0.0048）。习惯性慢跑者（每周 28 公里，n=30）的平均腰椎 VFF 为 31.3%（9.0%）（与参照者相比 p=0.22），在 T 、 T 、 T 椎体时比参照者低 6.0 个百分点（p≤0.023）。高负荷的公路自行车运动（每周 275 公里，n=22）并不影响 VFF。与快走、慢慢跑和高冲击活动相对应的 3D 加速度与较低的 VFF 相关，而低冲击活动和久坐时间与较高的平均腰椎 VFF 相关（所有 p≤0.05）。根据一生中脂肪性骨髓转换率估计为 7%，长距离跑步者 VFF 降低 5.6 个百分点，估计其椎体骨髓脂肪组织表型年轻 8 岁。回归分析显示，平均腰椎 VFF 每增加 9.4 公里/周，就会减少 0.7 个百分点（p=0.002）。这项研究首次在人类或动物中证明，特定的运动体积和类型可能会影响年龄相关的脂肪性骨髓转换，导致低 MAT。这些结果确定了一种潜在的可改变的危险因素，与骨代谢、造血生成和其他代谢功能相关的常见慢性疾病有关，具有潜在的全球健康应用价值。
