Programa de Química, Facultad de Ciencias Básicas y Tecnologías, Universidad del Quindío, Armenia, Quindío, Colombia.
Programa de Ingeniería de Alimentos, Facultad de Ciencias Agroindustriales, Universidad del Quindío, Armenia, Quindío, Colombia.
Int J Biol Macromol. 2018 May;111:498-504. doi: 10.1016/j.ijbiomac.2018.01.063. Epub 2018 Jan 11.
In recent years, starch nanoparticles have been of great interest for drug delivery due to their relatively easy synthesis, biocompatibility, and vast amount of botanical sources. Native and acetylated starch obtained from green bananas were used for synthesis of curcumin-loaded starch nanoparticles. Mean particle size, encapsulation efficiency, and curcumin release in simulated gastric and intestinal fluids were studied. Both nanosystems showed sizes lower than 250 nm and encapsulation efficiency above 80%, with acetylated banana starch nanoparticles having the capacity to encapsulate more curcumin molecules. Both FTIR and XRD analyses showed that starch acetylation allows stronger hydrogen bond interaction between curcumin and the starch matrix, thus, higher encapsulation efficiency. Finally, curcumin release studies showed that acetylated banana starch nanoparticles allowed more controlled release, probably due to their stronger hydrogen bond interaction with curcumin.
近年来，由于淀粉纳米粒子相对容易合成、生物相容性好且有大量植物来源，因此引起了人们对其作为药物传递载体的极大兴趣。本研究使用来源于绿香蕉的天然淀粉和乙酰化淀粉来合成载姜黄素的淀粉纳米粒子。研究了模拟胃液和肠液中的平均粒径、包封效率和姜黄素释放。两种纳米系统的粒径均小于 250nm，包封效率均高于 80%，其中乙酰化香蕉淀粉纳米粒子具有包封更多姜黄素分子的能力。傅里叶变换红外光谱和 X 射线衍射分析均表明，淀粉乙酰化允许姜黄素与淀粉基质之间形成更强的氢键相互作用，从而提高包封效率。最后，姜黄素释放研究表明，乙酰化香蕉淀粉纳米粒子允许更可控的释放，这可能是由于它们与姜黄素之间更强的氢键相互作用。
