酸-乙醇水解和去支链对乙酰化淀粉的影响及其作为姜黄素载体的潜力。
Effects of acid-ethanol hydrolysis and debranch on acetylated starch and its potential used for curcumin carrier.
机构信息
Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Wuxi 214122, Jiangsu Province, People's Republic of China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; Collaborative Innovation Center for Food Safety and Quality Control, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China.
Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Wuxi 214122, Jiangsu Province, People's Republic of China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; Collaborative Innovation Center for Food Safety and Quality Control, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China.
出版信息
Carbohydr Polym. 2022 Mar 1;279:119019. doi: 10.1016/j.carbpol.2021.119019. Epub 2021 Dec 20.
Acetylated acid-ethanol hydrolyzed (AHS) and acetylated debranched starch (ADS) were investigated as prospective nanocarriers. Both acid-ethanol hydrolysis and debranching decreased the molecular weight and viscosity of starch. Acid-ethanol hydrolyzed starch remained the original microstructure, which was confirmed by results of scanning electron microscopy. New absorption peaks in FTIR spectra of starch confirmed the occurrence of acetylation. The substitution degree (DS) of ADS could reach up to 1.18, while that of AHS could be improved by increasing the ethanol concentration. The developed nanoparticles showed uniform spherical structure and the size of that approximated 180-260 nm. The critical micelle concentration was 0.049 mg/mL, and the shift in fluorescence spectra confirmed the interaction between starch and curcumin. These results indicate show that high DS of AHS and ADS could be used as a potential carrier for curcumin delivery.
乙酰化酸-乙醇水解（AHS）和乙酰化支链淀粉（ADS）被研究为有前途的纳米载体。酸-乙醇水解和去支化都降低了淀粉的分子量和粘度。酸-乙醇水解淀粉保持了原始的微观结构，这一点通过扫描电子显微镜的结果得到了证实。淀粉的傅里叶变换红外光谱中出现了新的吸收峰，证实了乙酰化的发生。ADS 的取代度（DS）可达到 1.18，而通过增加乙醇浓度可以提高 AHS 的 DS。所开发的纳米颗粒具有均匀的球形结构，粒径约为 180-260nm。临界胶束浓度为 0.049mg/mL，荧光光谱的位移证实了淀粉和姜黄素之间的相互作用。这些结果表明，高 DS 的 AHS 和 ADS 可用作姜黄素递送的潜在载体。
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