tRNA 衍生的小非编码 RNA 在人类疾病中的作用。
tRNA-derived small non-coding RNAs in human disease.
机构信息
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China; Department of Thoracic Surgery, West China Hospital, Sichuan University, China.
出版信息
Cancer Lett. 2018 Apr 10;419:1-7. doi: 10.1016/j.canlet.2018.01.015. Epub 2018 Jan 11.
Besides attending protein synthesis, transfer RNA (tRNA) is an important regulatory non-coding RNA (ncRNA) that participates in various cellular processes, including cellular metabolism and cell death. Fragments generated from pre- or mature tRNAs by specific endonucleases cleavage (tRNA-derived small non-coding RNA [tsncRNAs]), rather than random degradation products, are newly defined functional small non-coding RNAs (sncRNAs). They can be regulated in bacteria, yeast, plants and animals to respond to stress conditions, resulting in regulation of gene expressions at both transcriptional and post-transcriptional level. Increasing evidence showed that the dysregulation of a series of tsncRNAs is associated with several types of human disease. In this review, we summarize the diversity and biogenesis of tsncRNAs in mammals and highlight the functions and mechanisms of different sub-classes of tsncRNAs in human disease.
除了参与蛋白质合成，转移 RNA（tRNA）还是一种重要的调节性非编码 RNA（ncRNA），参与多种细胞过程，包括细胞代谢和细胞死亡。由特定内切酶切割前体或成熟 tRNA 产生的片段（tRNA 衍生的小非编码 RNA [tsncRNA]），而不是随机降解产物，是新定义的功能小非编码 RNA（sncRNA）。它们可以在细菌、酵母、植物和动物中被调节，以响应应激条件，从而在转录和转录后水平上调节基因表达。越来越多的证据表明，一系列 tsncRNA 的失调与几种类型的人类疾病有关。在这篇综述中，我们总结了哺乳动物中 tsncRNA 的多样性和生物发生，并强调了不同亚类的 tsncRNA 在人类疾病中的功能和机制。
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