Key Laboratory of Colloid and Interface Chemistry & Key Laboratory of Special Aggregated Materials, Shandong University, Ministry of Education , Jinan 250100, P. R. China.
Department of Chemistry, Western Kentucky University , Bowling Green, Kentucky 42101, United States.
ACS Appl Mater Interfaces. 2018 Feb 14;10(6):5348-5357. doi: 10.1021/acsami.7b18689. Epub 2018 Jan 30.
To endow valuable responsiveness to self-assemblies of Au nanoparticles (Au NPs), the magnetic Au nanoparticles (Au NPs)/CH(CH)N[CeClBr] (CTACe) mixtures were first prepared by using an emulsion self-assembly of a magnetic surfactant, CH(CH)N[CeClBr]. A versatile morphology of self-assemblies of Au NPs could be controlled by the counterions in surfactants including [CeClBr], [FeClBr], and Br as well as solvent. In particular, the magnetic counterion, [CeClBr], can induce self-growth of Au NPs in an emulsion self-assembly process due to the oxidability of [CeClBr]. It enhances the rigidity of Au NPs/CTACe scaffolds template compared with Au NPs/hexadecyltrimethylammonium bromide. [CeClBr] engaged Au NPs/CTACe with fascinating capability of conglutination and targeted migration of DNA (150 μmol/L) under a magnet field. The conglutination capability of the DNA molecules can increase to 39.8% by adopting the magnetic strategy when using Au NPs/CTACe as a magnetic booster. Au NPs/CTACe mixtures can ideally self-assemble to be scaffolds, providing abundant conjugation sites of surface charges. Magnetic Au NPs/CTACe can serve as a template scaffold to secondary self-assemble with DNA (40 mmol/L) outside, producing smooth-faced and hollow DNA nanocapsules. We believe that the creative Au NPs/CTACe/DNA nanocapsules will extend the biological application field of Au NPs assemblies.
为了赋予金纳米粒子（Au NPs）自组装体系宝贵的响应性，首次通过磁性表面活性剂 CH(CH)N[CeClBr]（CTACe）的乳液自组装制备了磁性 Au 纳米粒子（Au NPs）/CH(CH)N[CeClBr]（CTACe）混合物。Au NPs 自组装体系的多种形态可以通过包括[CeClBr]、[FeClBr]和 Br 在内的反离子以及溶剂来控制。特别是，磁性反离子[CeClBr]可以由于[CeClBr]的氧化性而在乳液自组装过程中诱导 Au NPs 的自生长。它增强了 Au NPs/CTACe 支架模板的刚性，与 Au NPs/十六烷基三甲基溴化铵相比。[CeClBr]使 Au NPs/CTACe 具有在磁场下黏附和靶向迁移 DNA（150 μmol/L）的迷人能力。当采用 Au NPs/CTACe 作为磁增强剂时，采用磁策略可以将 DNA 分子的黏附能力提高到 39.8%。Au NPs/CTACe 混合物可以理想地自组装成支架，提供丰富的表面电荷结合位点。磁性 Au NPs/CTACe 可以作为模板支架与外部的 DNA（40 mmol/L）进行二次自组装，产生光滑的中空 DNA 纳米胶囊。我们相信，创造性的 Au NPs/CTACe/DNA 纳米胶囊将扩展 Au NPs 组装的生物应用领域。
