Key Laboratory of Colloid and Interface Chemistry & Key Laboratory of Special Aggregated Materials , Shandong University, Ministry of Education , Jinan 250100 , P. R. China.
School of Chemistry , University of Bristol , Cantock's Close , Bristol BS8 1TS , U.K.
Langmuir. 2018 Jun 19;34(24):7171-7179. doi: 10.1021/acs.langmuir.8b01445. Epub 2018 Jun 8.
Developing nontoxic artificial carriers for stimuli-responsive capture, transport, and delivery of biomolecules is of immense scientific interest. Herein, for the first time, we synthesize a double-tailed cationic surfactant, (CH)(CH)N[FeClBr], which possesses magnetic properties [magnetic surfactants (Mag-Surfs)]. The time-dependent formation of virus-shaped hybrid mixed assemblies of polyoxometalates (POMs) {MoFe}/Mag-Surf with hollow-shell structures is followed. These structures serve well as robust high-surface-area shuttles, which can be manipulated with applied magnetic fields. By using cationic Mag-Surfs, the anionic POMs and DNA can be complexed in these ternary mixtures. These virus-shaped complexes act as nanoanchors and nanomotors, which can be utilized for binding, anchoring, and delivery of biomolecules, such as DNA. It is found that they have a good absorption capacity for DNA and myoglobin over 24 h, after application of a magnetic field. The realization of magnetic virus-shaped {MoFe}/Mag-Surf spheres may open possibilities for designing other functional nanoparticles, allowing effective control over the delivery/separation of biomolecules.
开发对刺激响应的生物分子捕获、传输和递送具有非毒性的人工载体具有重要的科学意义。本文首次合成了一种具有磁性的双尾阳离子表面活性剂(CH)(CH)N[FeClBr]，即磁性表面活性剂（Mag-Surfs）。随后，研究了多酸（POMs）{MoFe}与具有中空壳结构的混合组装体的病毒状杂交混合组装体的时间依赖性形成。这些结构可以作为坚固的高表面积穿梭物，通过施加磁场进行操作。通过使用阳离子 Mag-Surfs，可以将阴离子 POMs 和 DNA 复合在这些三元混合物中。这些病毒状复合物可作为纳米锚和纳米马达，用于结合、固定和输送生物分子，如 DNA。实验发现，在施加磁场后，它们对 DNA 和肌红蛋白的吸附能力在 24 小时内仍然很好。实现磁性病毒状{MoFe}/Mag-Surf 球体可能为设计其他功能纳米粒子开辟可能性，从而可以有效地控制生物分子的输送/分离。
