Orychophragmine A-C，三种来自菘蓝叶虫实的生物活性生物碱。
Orychophragines A-C, Three Biologically Active Alkaloids from Orychophragmus violaceus.
机构信息
Beijing Institute of Radiation Medicine , Beijing 100850, People's Republic of China.
Beijing University of Technology , Beijing 100124, People's Republic of China.
出版信息
Org Lett. 2018 Feb 2;20(3):656-659. doi: 10.1021/acs.orglett.7b03801. Epub 2018 Jan 17.
Orychophragines A-C (1-3), three new alkaloids with an novel 2-piperazinone-fused 2,4-dioxohexahydro-1,3,5-triazine skeleton, were isolated from the seeds of Orychophragmus violaceus. Their structures were established on the basis of spectroscopic analysis and X-ray crystallographic analysis. Orychophragines A (1) exhibited remarkable cytotoxicity against HepG2, A549, Hela, and HCT-116 cells with IC values of 7.73, 10.79, 11.91, and 9.93 μM, respectively. Orychophragines C (3) showed moderate Co γ radiation protection activity in HUVEC cells. A plausible biosynthetic pathway for 1-3 was proposed.
藜芦定 A-C（1-3），三种新型生物碱，具有新颖的 2-哌嗪酮融合的 2,4-二氧代六氢-1,3,5-三嗪骨架，从藜芦的种子中分离得到。它们的结构是基于光谱分析和 X 射线晶体学分析确定的。藜芦定 A（1）对 HepG2、A549、Hela 和 HCT-116 细胞表现出显著的细胞毒性，IC 值分别为 7.73、10.79、11.91 和 9.93 μM。藜芦定 C（3）在 HUVEC 细胞中表现出中等的 Co γ 辐射保护活性。提出了 1-3 的可能生物合成途径。
Zotero 插件