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Combating Carbapenem-Resistant Acinetobacter baumannii by an Optimized Imipenem-plus-Tobramycin Dosage Regimen: Prospective Validation via Hollow-Fiber Infection and Mathematical Modeling.优化亚胺培南-妥布霉素剂量方案对抗碳青霉烯类耐药鲍曼不动杆菌：中空纤维感染和数学建模的前瞻性验证。
Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.02053-17. Print 2018 Apr.
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Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii.优化碳青霉烯类抗生素与氨基糖苷类抗生素联合使用以对抗耐碳青霉烯鲍曼不动杆菌的新方法。
Antimicrob Agents Chemother. 2015 Apr;59(4):2286-98. doi: 10.1128/AAC.04379-14. Epub 2015 Feb 2.
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Optimization of Synergistic Combination Regimens against Carbapenem- and Aminoglycoside-Resistant Clinical Pseudomonas aeruginosa Isolates via Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling.通过基于机制的药代动力学/药效学模型优化针对耐碳青霉烯类和氨基糖苷类的临床铜绿假单胞菌分离株的协同联合治疗方案。
Antimicrob Agents Chemother. 2016 Dec 27;61(1). doi: 10.1128/AAC.01011-16. Print 2017 Jan.
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Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling.通过机制研究和建模确定与碳青霉烯类药物协同作用所需的氨基糖苷类药物浓度对铜绿假单胞菌。
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.00722-17. Print 2017 Dec.
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Optimization and Evaluation of Piperacillin-Tobramycin Combination Dosage Regimens against Pseudomonas aeruginosa for Patients with Altered Pharmacokinetics via the Hollow-Fiber Infection Model and Mechanism-Based Modeling.通过中空纤维感染模型和基于机制的建模优化和评估哌拉西林-他唑巴坦组合剂量方案对药代动力学改变的铜绿假单胞菌感染患者的疗效。
Antimicrob Agents Chemother. 2018 Apr 26;62(5). doi: 10.1128/AAC.00078-18. Print 2018 May.
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Antibiotic combinations for serious infections caused by carbapenem-resistant Acinetobacter baumannii in a mouse pneumonia model.用于小鼠肺炎模型中耐碳青霉烯鲍曼不动杆菌引起的严重感染的抗生素联合用药
J Antimicrob Chemother. 2004 Dec;54(6):1085-91. doi: 10.1093/jac/dkh485. Epub 2004 Nov 16.
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Optimization of a Meropenem-Tobramycin Combination Dosage Regimen against Hypermutable and Nonhypermutable Pseudomonas aeruginosa via Mechanism-Based Modeling and the Hollow-Fiber Infection Model.通过基于机制的建模和中空纤维感染模型优化美罗培南-妥布霉素联合方案治疗高突变和非高突变铜绿假单胞菌。
Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.02055-17. Print 2018 Apr.
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Evaluation of Pharmacokinetic/Pharmacodynamic Model-Based Optimized Combination Regimens against Multidrug-Resistant Pseudomonas aeruginosa in a Murine Thigh Infection Model by Using Humanized Dosing Schemes.基于药代动力学/药效学模型的优化组合方案对人用量方案治疗多重耐药铜绿假单胞菌小鼠大腿感染模型的评价。
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.01268-17. Print 2017 Dec.
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Meropenem-Tobramycin Combination Regimens Combat Carbapenem-Resistant Pseudomonas aeruginosa in the Hollow-Fiber Infection Model Simulating Augmented Renal Clearance in Critically Ill Patients.美罗培南-妥布霉素联合方案在模拟重症患者增强肾脏清除率的中空纤维感染模型中对抗耐碳青霉烯铜绿假单胞菌。
Antimicrob Agents Chemother. 2019 Dec 20;64(1). doi: 10.1128/AAC.01679-19.
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Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii.利用机器学习优化抗生素组合：美罗培南和多粘菌素B对耐碳青霉烯鲍曼不动杆菌的给药策略
Clin Microbiol Infect. 2020 Sep;26(9):1207-1213. doi: 10.1016/j.cmi.2020.02.004. Epub 2020 Feb 12.
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Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in media, and novel supplement dosing strategy to mitigate thermal drug degradation.在介质中对 13 种β-内酰胺类抗生素和β-内酰胺酶抑制剂进行综合稳定性分析，并提出新的补充剂量策略以减轻热药物降解。
Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0139923. doi: 10.1128/aac.01399-23. Epub 2024 Feb 8.
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Combating Multidrug-Resistant Bacteria by Integrating a Novel Target Site Penetration and Receptor Binding Assay Platform Into Translational Modeling.通过将新型靶位渗透和受体结合分析平台整合到转化模型中，来对抗多药耐药菌。
Clin Pharmacol Ther. 2021 Apr;109(4):1000-1020. doi: 10.1002/cpt.2205. Epub 2021 Mar 24.
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Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii.利用机器学习优化抗生素组合：美罗培南和多粘菌素B对耐碳青霉烯鲍曼不动杆菌的给药策略
Clin Microbiol Infect. 2020 Sep;26(9):1207-1213. doi: 10.1016/j.cmi.2020.02.004. Epub 2020 Feb 12.
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Meropenem-Tobramycin Combination Regimens Combat Carbapenem-Resistant Pseudomonas aeruginosa in the Hollow-Fiber Infection Model Simulating Augmented Renal Clearance in Critically Ill Patients.美罗培南-妥布霉素联合方案在模拟重症患者增强肾脏清除率的中空纤维感染模型中对抗耐碳青霉烯铜绿假单胞菌。
Antimicrob Agents Chemother. 2019 Dec 20;64(1). doi: 10.1128/AAC.01679-19.
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When One Drug Is Not Enough: Context, Methodology, and Future Prospects in Antibacterial Synergy Testing.当一种药物不足时：抗菌协同试验的背景、方法及未来前景
Clin Lab Med. 2019 Sep;39(3):345-358. doi: 10.1016/j.cll.2019.04.002. Epub 2019 Jun 12.
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Pharmacodynamic Drug-Drug Interactions.药效学药物-药物相互作用。
Clin Pharmacol Ther. 2019 Jun;105(6):1395-1406. doi: 10.1002/cpt.1434. Epub 2019 Apr 26.
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Generating Robust and Informative Nonclinical and Bacterial Infection Model Efficacy Data To Support Translation to Humans.生成稳健且信息丰富的非临床和细菌感染模型药效数据，以支持向人体的转化。
Antimicrob Agents Chemother. 2019 Apr 25;63(5). doi: 10.1128/AAC.02307-18. Print 2019 May.
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Meropenem Combined with Ciprofloxacin Combats Hypermutable Pseudomonas aeruginosa from Respiratory Infections of Cystic Fibrosis Patients.美罗培南联合环丙沙星对抗囊性纤维化患者呼吸道感染的高突变铜绿假单胞菌。
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.01150-18. Print 2018 Nov.
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Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis.四十年来囊性纤维化患者β-内酰胺类抗生素的药代动力学研究
Clin Pharmacokinet. 2019 Feb;58(2):143-156. doi: 10.1007/s40262-018-0678-x.
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Dilution Factor of Quantitative Bacterial Cultures Obtained by Bronchoalveolar Lavage in Patients with Ventilator-Associated Bacterial Pneumonia.机械通气相关性细菌性肺炎患者支气管肺泡灌洗液定量细菌培养的稀释系数。
Antimicrob Agents Chemother. 2017 Dec 21;62(1). doi: 10.1128/AAC.01323-17. Print 2018 Jan.
2
Evaluation of Pharmacokinetic/Pharmacodynamic Model-Based Optimized Combination Regimens against Multidrug-Resistant Pseudomonas aeruginosa in a Murine Thigh Infection Model by Using Humanized Dosing Schemes.基于药代动力学/药效学模型的优化组合方案对人用量方案治疗多重耐药铜绿假单胞菌小鼠大腿感染模型的评价。
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.01268-17. Print 2017 Dec.
3
Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling.通过机制研究和建模确定与碳青霉烯类药物协同作用所需的氨基糖苷类药物浓度对铜绿假单胞菌。
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.00722-17. Print 2017 Dec.
4
Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges.不动杆菌感染的临床与病理生理学概述：一个世纪的挑战
Clin Microbiol Rev. 2017 Jan;30(1):409-447. doi: 10.1128/CMR.00058-16.
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Optimization of Synergistic Combination Regimens against Carbapenem- and Aminoglycoside-Resistant Clinical Pseudomonas aeruginosa Isolates via Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling.通过基于机制的药代动力学/药效学模型优化针对耐碳青霉烯类和氨基糖苷类的临床铜绿假单胞菌分离株的协同联合治疗方案。
Antimicrob Agents Chemother. 2016 Dec 27;61(1). doi: 10.1128/AAC.01011-16. Print 2017 Jan.
6
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.混合抗生素通过增强外膜穿透性和减少外排来克服铜绿假单胞菌的耐药性。
J Med Chem. 2016 Sep 22;59(18):8441-55. doi: 10.1021/acs.jmedchem.6b00867. Epub 2016 Aug 30.
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Adjuvants Based on Hybrid Antibiotics Overcome Resistance in Pseudomonas aeruginosa and Enhance Fluoroquinolone Efficacy.基于混合抗生素的佐剂克服铜绿假单胞菌的耐药性并增强氟喹诺酮类药物的疗效。
Angew Chem Int Ed Engl. 2016 Jan 11;55(2):555-9. doi: 10.1002/anie.201508330. Epub 2015 Nov 26.
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Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii.优化碳青霉烯类抗生素与氨基糖苷类抗生素联合使用以对抗耐碳青霉烯鲍曼不动杆菌的新方法。
Antimicrob Agents Chemother. 2015 Apr;59(4):2286-98. doi: 10.1128/AAC.04379-14. Epub 2015 Feb 2.
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Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling.通过基于机制的模型在多个接种量下评估妥布霉素杀灭铜绿假单胞菌的两种机制。
Antimicrob Agents Chemother. 2015 Apr;59(4):2315-27. doi: 10.1128/AAC.04099-14. Epub 2015 Feb 2.
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Clinical implications of cefazolin inoculum effect and β-lactamase type on methicillin-susceptible Staphylococcus aureus bacteremia.头孢唑林接种物效应及β-内酰胺酶类型对甲氧西林敏感金黄色葡萄球菌菌血症的临床影响
Microb Drug Resist. 2014 Dec;20(6):568-74. doi: 10.1089/mdr.2013.0229.
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