Jamilian Abdolreza, Sarkarat Farzin, Jafari Mehrdad, Neshandar Morteza, Amini Ehsan, Khosravi Saeed, Ghassemi Alireza
No 14, Pesiyan St., Vali Asr St. Tehran 1986944768, Iran.
Stomatologija. 2017;19(3):78-83.
Several environmental and genetic issues have been suspected as risk factors for oral clefts; and many studies have been conducted in this regard; however, large socioeconomic impacts of cleft lip and or palate (CL/P) justifies the need for further multifactorial researches. Current study aimed to assess parental risk factors for CL/P and its associated malformations.
Hospital records of 187 consecutive syndromic and non-syndromic children with cleft lip and or palate (103 boys and 84 girls) with a mean age of 1.7 (SD 2.2) years and 190 consecutive non-cleft children (103 boys and 87 girls) with a mean age of 2.8 (SD 2.2) years formed this study. Parental risk factors and abnormalities and physical problems and anomalies were evaluated in all subjects.
Family history of clefts (OR 7.4; 95% CI), folic acid consumption (OR 7.3; 95% CI) and consanguineous marriage (OR 3.2; 95% CI) were quite strongly associated with increased risk of CL/P. In addition, all congenital abnormalities and physical problems had significantly higher incidence in CL/P patients.
The findings of this study suggest that expecting mothers of consanguineous marriage and families with a history of CL/P should be extra cautious about the occurrence of CL/P.
多种环境和遗传因素被怀疑是口腔裂隙的风险因素；对此已经开展了许多研究；然而，唇腭裂（CL/P）对社会经济产生的重大影响证明有必要进行进一步的多因素研究。本研究旨在评估CL/P及其相关畸形的父母风险因素。
本研究纳入了187例连续的综合征型和非综合征型唇腭裂患儿（103例男孩和84例女孩），平均年龄1.7岁（标准差2.2岁），以及190例连续的非腭裂患儿（103例男孩和87例女孩），平均年龄2.8岁（标准差2.2岁）。对所有受试者评估父母风险因素、异常情况、身体问题和畸形。
腭裂家族史（比值比7.4；95%置信区间）、叶酸摄入（比值比7.3；95%置信区间）和近亲结婚（比值比3.2；95%置信区间）与CL/P风险增加密切相关。此外，所有先天性异常和身体问题在CL/P患者中的发生率显著更高。
本研究结果表明，近亲结婚的孕妇以及有CL/P家族史的家庭应格外警惕CL/P的发生。
