Alkhattabi Fadiah, Aljohar Aziza, Alharbi Atheer, Alsalman Munirah, Alhuthil Raghad, Almuabyedh Alaa, Alsagheir Afaf, Aljarba Ebtisam
Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Saudi J Med Med Sci. 2025 Apr-Jun;13(2):142-148. doi: 10.4103/sjmms.sjmms_253_24. Epub 2025 Apr 21.
Cleft lip and palate (CLP) can have an impact on the physical development of children; however, data from such studies is currently limited.
To compare growth parameters between children with non-syndromic CLP and healthy controls in Saudi Arabia.
This case-control retrospective cohort study included Saudi children with CLP and age- and gender-matched healthy children (1:1) who attended a tertiary care center in Riyadh, Saudi Arabia. Growth measurements (weight, length, and head circumference) were taken at the ages of 1 year and 2 years, and the Saudi Growth Chart was used as a reference data.
The study included 86 children in each group ( = 172), with 31.4% females and 68.6% males. The mean current age was 3.2 ± 1.7 years. Most patients had a unilateral CLP (96.5%). Multivariable analysis demonstrated that at the age of 1 year, compared with controls, patients with CLP had significantly lower weight (OR: 1.7, = 0.026), weight standard deviation score (SDS) (OR: 0.4, = 0.001), and head circumference SDS (OR: 0.8, <0.001); however, these did not remain significant at the age of 2 years. In the early repair (age <1 year) and late repair (age ≥1 year) groups, 76.1% and 63.2% of the patients achieved catch-up growth.
This study found that Saudi children with cleft lip and palate had significantly lower weight and head circumference compared with healthy children in the first year of life, but catch-up growth in the second year of life, largely following surgical repair, rendered these differences to be insignificant.
唇腭裂（CLP）会对儿童的身体发育产生影响；然而，此类研究的数据目前有限。
比较沙特阿拉伯非综合征性唇腭裂儿童与健康对照儿童的生长参数。
本病例对照回顾性队列研究纳入了沙特阿拉伯利雅得一家三级医疗中心的唇腭裂沙特儿童以及年龄和性别匹配的健康儿童（1:1）。在1岁和2岁时进行生长测量（体重、身长和头围），并以沙特生长图表作为参考数据。
每组纳入86名儿童（n = 172），其中女性占31.4%，男性占68.6%。当前平均年龄为3.2±1.7岁。大多数患者为单侧唇腭裂（96.5%）。多变量分析表明，在1岁时，与对照组相比，唇腭裂患者的体重显著更低（OR：1.7，P = 0.026）、体重标准差评分（SDS）显著更低（OR：0.4，P = 0.001）以及头围SDS显著更低（OR：0.8，P<0.001）；然而，在2岁时这些差异不再显著。在早期修复组（年龄<1岁）和晚期修复组（年龄≥1岁）中，分别有76.1%和63.2%的患者实现了追赶生长。
本研究发现，沙特唇腭裂儿童在出生后第一年的体重和头围显著低于健康儿童，但在出生后第二年，在很大程度上通过手术修复实现了追赶生长，使得这些差异变得不显著。
