Sanko University Faculty of Medicine,Gaziantep - Turquia.
Adiyaman University Education and Research Hospital - Cardiology,Adıyaman, Century - Turquia.
Arq Bras Cardiol. 2021 Jan;116(1):48-54. doi: 10.36660/abc.20190476.
Coronary artery ectasia (CAE) is defined as diffuse or localized dilatation of coronary artery lumen with a diameter of 1.5 to 2.0 times the adjacent normal coronary artery. The C-reactive protein to albumin ratio (CAR) is a useful inflammatory marker, which has been documented in coronary artery disease.
To analyze the association of CAE and CAR.
A case-control protocol was used in this study. We included 102 consecutive patients with isolated CAE without stenosis (56 men and 46 women; mean age 60.4 ± 8.8 years). The control subjects consisted of an equal number of sex and age matched patients with normal coronary arteries (55 men and 47 women; mean age 61.2 ± 9.1 years). Clinical features, laboratory findings, and medication use history were recorded. Student's t test, Mann-Whitney U test, chi-square test, and linear and logistic regression analysis were performed. A 2-sided p < 0.05 was statistically considered significant.
The CAR was increased in patients with CAE compared to the controls (32 and 16; p < 0.001). In addition, the CAR was found to be an independent predictor of CAE (OR = 2.202; 95% CI 1.184 - 5.365; p < 0.001).
In the present study, we determined that CAR levels were significantly higher in the CAE group than in the control group, and the CAR was significantly correlated with CAE. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0).
冠状动脉扩张（CAE）是指冠状动脉管腔弥漫性或局限性扩张，直径为相邻正常冠状动脉的 1.5 至 2.0 倍。C 反应蛋白与白蛋白比值（CAR）是一种有用的炎症标志物，已在冠状动脉疾病中得到证实。
分析 CAE 与 CAR 的相关性。
本研究采用病例对照方案。我们纳入了 102 例连续的孤立性无狭窄的 CAE 患者（56 名男性和 46 名女性；平均年龄 60.4 ± 8.8 岁）。对照组由性别和年龄与之相匹配的冠状动脉正常患者组成（55 名男性和 47 名女性；平均年龄 61.2 ± 9.1 岁）。记录临床特征、实验室检查结果和用药史。采用学生 t 检验、Mann-Whitney U 检验、卡方检验、线性和逻辑回归分析。双侧 p<0.05 为统计学显著差异。
与对照组相比，CAE 患者的 CAR 升高（32 与 16；p<0.001）。此外，CAR 被发现是 CAE 的独立预测因子（OR=2.202；95%CI 1.184-5.365；p<0.001）。
在本研究中，我们确定 CAE 组的 CAR 水平明显高于对照组，并且 CAR 与 CAE 显著相关。（Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0）。
