巴西东北部阿拉戈斯州人类汉坦病毒感染的首例血清学证据。
First serologic evidence of human hantavirus infection in Alagoas State in Northeastern Brazil.
作者信息
Santos-Júnior José Alfredo Dos, Santos Flávio Martins Dos, Barros Patrícia Alves, Medeiros Nedja Poliane Torres, Sabino-Santos Júnior Gilberto, Lima Magliones Carneiro de, Figueiredo Luiz Tadeu Moraes, Borges Alessandra Abel
机构信息
Laboratório de Pesquisas em Virologia e Imunologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Alagoas, Maceió, AL, Brasil.
Centro de Pesquisa em Virologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
出版信息
Rev Soc Bras Med Trop. 2017 Nov-Dec;50(6):819-823. doi: 10.1590/0037-8682-0117-2017.
INTRODUCTION
Hantavirus cardiopulmonary syndrome (HCPS) is rare in Northeastern Brazil.
METHODS
Prospective surveillance was conducted over a two-year period in Alagoas State, Northeastern Brazil. The prevalence of anti-hantavirus N-antigen IgM and IgG in human serum samples was determined by enzyme-linked immunosorbent assay testing.
RESULTS
High avidity IgG was found in nine of 476 serum samples tested (from 102 patients with clinical manifestations compatible with HCPS, 124 patients with leptospirosis, and 250 healthy rural workers).
CONCLUSIONS
Serologic evidence of past hantavirus infection in residents of Alagoas State indicates that hantaviruses are present in northeastern Brazil, even in areas silent for HCPS.
引言
汉坦病毒心肺综合征（HCPS）在巴西东北部较为罕见。
方法
在巴西东北部阿拉戈斯州进行了为期两年的前瞻性监测。通过酶联免疫吸附试验检测人血清样本中抗汉坦病毒N抗原IgM和IgG的流行情况。
结果
在检测的476份血清样本中，有9份（来自102例临床表现符合HCPS的患者、124例钩端螺旋体病患者和250名健康农村工人）发现了高亲和力IgG。
结论
阿拉戈斯州居民过去感染汉坦病毒的血清学证据表明，巴西东北部存在汉坦病毒，即使在HCPS无病例报告的地区也是如此。
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