巴西圣保罗州卡西亚斯杜科埃罗县汉坦病毒感染的回顾性血清学调查。
A retrospective serologic survey of hantavirus infections in the county of Cássia dos Coqueiros, State of São Paulo, Brazil.
机构信息
Departamento de Saúde Pública, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
出版信息
Rev Soc Bras Med Trop. 2012 Jul-Aug;45(4):468-70. doi: 10.1590/s0037-86822012005000005. Epub 2012 Jul 5.
INTRODUCTION
In recent years, hantavirus infections producing severe diseases have obtained an increased attention from public health authorities from the countries of Eurasia to the Americas. Brazil has reported 1,300 cases of hantavirus cardiopulmonary syndrome (HCPS) from 1993 to 2010, with about 80 of them occurring in the northeast of the State of São Paulo, with 48% fatality rate. Araraquara virus was the causative agent of HCPS in the region. Considering that hantaviruses causing human disease in the Americas were unknown until 1993, we have looked for hantavirus infections in the population of Cássia dos Coqueiros county, northeast of the State of São Paulo, Brazil, before this time. This county has about 2,800 inhabitants and an economy based on agriculture, including cultivation of Brachiaria decumbens grass. The grass seeds are an important rodent attraction, facilitating transmission of hantavirus to man. Four HCPS cases were reported so far in the county.
METHODS
In this study, 1,876 sera collected from 1987 to 1990 were tested for IgG to hantavirus by IgG-ELISA, using the N recombinant protein of Araraquara virus as antigen.
RESULTS
Positive results were observed in 89 (4.7%) samples, which were all collected in 1987. The positivity among urban inhabitants was 5.3%, compared with 4.3% among those living in rural areas.
CONCLUSIONS
Our results showed that hantavirus infections occurred in Cássia dos Coqueiros, completely unrecognized, even before hantaviruses were described in the Americas.
简介
近年来，欧亚大陆到美洲的各国公共卫生当局越来越关注引起严重疾病的汉坦病毒感染。巴西报告了 1993 年至 2010 年的 1300 例汉坦病毒心肺综合征（HCPS）病例，其中约 80 例发生在圣保罗州东北部，死亡率为 48%。该地区 HCPS 的病原体是 Araraquara 病毒。考虑到直到 1993 年，在美洲引起人类疾病的汉坦病毒才为人所知，因此我们在巴西圣保罗州东北部的 Cássia dos Coqueiros 县的人群中寻找汉坦病毒感染，在此之前。该县约有 2800 名居民，经济以农业为基础，包括种植 Brachiaria decumbens 草。草籽是吸引啮齿动物的重要因素，有利于汉坦病毒向人类传播。该县迄今已报告了 4 例 HCPS 病例。
方法
本研究使用 Araraquara 病毒的 N 重组蛋白作为抗原，通过 IgG-ELISA 检测了 1987 年至 1990 年采集的 1876 份血清中针对汉坦病毒的 IgG。
结果
在 89 份（4.7%）样本中观察到阳性结果，这些样本均于 1987 年采集。城市居民的阳性率为 5.3%，而农村居民的阳性率为 4.3%。
结论
我们的结果表明，在汉坦病毒被描述在美洲之前，Cássia dos Coqueiros 县就已经发生了汉坦病毒感染，而且完全没有被认识到。
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