Baker D A, Hameed C, Tejani N, Milch P, Thomas J, Monheit A G, Dattwyler R J
Contraception. 1985 Oct;32(4):377-82. doi: 10.1016/0010-7824(85)90041-1.
Oral contraceptive users have been reported to have a higher incidence of viral, bacterial and fungal infections. This study was undertaken to try to elucidate some of the mechanisms responsible for this increased susceptibility to infection. Peripheral blood lymphocytes were labelled with murine monoclonal antibodies directed against T cells and the various lymphocyte subsets: helper cells, suppressor/cytotoxic cells, or natural killer cells. The lymphocytes were then analyzed on a Coulter Electronics Epics V fluorescent activated cell sorter (FACS). A total of 27 control and 33 oral contraceptive users were studied. In comparison to the control group, there was no significant difference between the two groups in percentage or absolute numbers of total T cells, helper cells, suppressor/cytotoxic cells or natural killer cells. This study suggests that the increase in herpes virus, C. trachomonas, candida, and other infections in women taking oral contraceptives is not related to alterations in the numbers of T lymphocyte subsets or in levels of NK cells.
据报道，口服避孕药使用者感染病毒、细菌和真菌的发生率较高。本研究旨在试图阐明导致这种感染易感性增加的一些机制。用针对T细胞和各种淋巴细胞亚群（辅助细胞、抑制/细胞毒性细胞或自然杀伤细胞）的鼠单克隆抗体标记外周血淋巴细胞。然后在库尔特电子公司的Epics V荧光激活细胞分选仪（FACS）上分析淋巴细胞。共研究了27名对照组和33名口服避孕药使用者。与对照组相比，两组在总T细胞、辅助细胞、抑制/细胞毒性细胞或自然杀伤细胞的百分比或绝对数量上没有显著差异。本研究表明，服用口服避孕药的女性中疱疹病毒、沙眼衣原体、念珠菌和其他感染的增加与T淋巴细胞亚群数量或NK细胞水平的改变无关。
