Jungwirth Nicole, Junginger Johannes, Andrijczuk Christoph, Baumgärtner Wolfgang, Wohlsein Peter
1 Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.
2 Center for Systems Neuroscience, Hannover, Germany.
Vet Pathol. 2018 May;55(3):453-456. doi: 10.1177/0300985817747949. Epub 2018 Jan 17.
Plexiform vasculopathy refers to an endothelial proliferative disorder affecting cervical or inguinal lymph nodes of cats. The cause of this disorder and the origin of the proliferating endothelial cells are still unknown. In 4 cats with a history of a slowly growing, well-demarcated, nonpainful mass adjacent to the thyroid gland, an enlarged dark brown to red lymph node was removed. Histologically, the lymph nodes showed severe loss of lymphoid tissue with accumulations of erythrocytes. In addition, networks of capillary structures with well-differentiated endothelial cells on a collagen-rich stroma were observed, consistent with benign plexiform vasculopathy. Immunohistochemistry revealed the expression of the vascular endothelial markers CD31 and factor VIII-related antigen. In addition, immunolabeling with a Prox-1 antibody indicated a lymphendothelial origin. With respect to our findings, a lymphendothelial origin has to be considered in cases of intranodal vascular neoplasms.
丛状血管病是一种影响猫颈部或腹股沟淋巴结的内皮细胞增生性疾病。这种疾病的病因以及增生的内皮细胞的起源尚不清楚。在4只患有甲状腺旁缓慢生长、边界清晰、无痛性肿块病史的猫中，切除了一个肿大的深棕色至红色淋巴结。组织学上，淋巴结显示淋巴组织严重缺失，有红细胞积聚。此外，观察到在富含胶原蛋白的基质上有毛细血管结构网络，内皮细胞分化良好，符合良性丛状血管病。免疫组化显示血管内皮标志物CD31和因子VIII相关抗原的表达。此外，用Prox-1抗体进行免疫标记表明其起源于淋巴管内皮。根据我们的研究结果，对于淋巴结内血管肿瘤病例，必须考虑淋巴管内皮起源。
