Mazzotta Elisabetta, De Santo Marzia, Lombardo Domenico, Leggio Antonella, Pasqua Luigi
Experimental Neurology Unit, School of Medicine and Surgery and Milan Center for Neuroscience, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende (CS), Italy.
Mater Today Bio. 2022 Oct 21;17:100472. doi: 10.1016/j.mtbio.2022.100472. eCollection 2022 Dec 15.
In this review, the most valuable opportunities offered by mesoporous silica nanoparticles in the field of development of nanodevices for bionanotechnology applications are reviewed. The state of the art is critically discussed with particular emphasis on cancer-related application, paying attention to all the aspects of the design and development of the process that engineers the selective administration of an anticancer agent to cancer tissues. The analyses of the critical factors that limit this process are taken into account and the technical solutions proposed to face these factors are discussed. Furthermore, targeting to difficult tissues and forefront applications such as cancer immunotherapy, diagnostic, theranostic, and gene therapy are considered. Lastly, the authors provide their opinion on the reasons according to which the translation of this generation of nanodevices from laboratory research into practical clinical and eventually into the market is possible.
在本综述中，我们回顾了介孔二氧化硅纳米颗粒在生物纳米技术应用的纳米器件开发领域所提供的最具价值的机遇。对当前的技术水平进行了批判性讨论，特别强调了与癌症相关的应用，关注了设计和开发将抗癌剂选择性输送到癌组织过程的各个方面。考虑了对这一过程产生限制的关键因素分析，并讨论了为应对这些因素而提出的技术解决方案。此外，还考虑了针对诸如癌症免疫疗法、诊断、治疗诊断和基因治疗等难以处理的组织和前沿应用的靶向性。最后，作者就这一代纳米器件从实验室研究转化为实际临床应用并最终推向市场的可能性给出了他们的看法。
