Liu Tianrun, Men Qianqian, Su Xuan, Chen Weichao, Zou Lan, Li Qiuli, Song Ming, Ouyang Dian, Chen Yanfeng, Li Zhaoqu, Fu Xiaoyan, Yang Ankui
Department of Otorhinolaryngology Head and Neck Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China.
Graceland Medical Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China.
Oncol Lett. 2017 Dec;14(6):7506-7512. doi: 10.3892/ol.2017.7122. Epub 2017 Oct 3.
In differentiated thyroid cancer (DTC), the association between thyroid-stimulating hormone receptor (TSHR) and metastasis, and the underlying molecular mechanisms remain unclear. The role of TSHR in the epithelial-mesenchymal transition (EMT) has not yet been reported, to the best of our knowledge. In the present study, the role of TSHR in the distant metastasis of DTC was investigated. TSHR was significantly downregulated in well-differentiated thyroid cancer cells and tissues, and a lack of TSHR promoted thyroid cancer cell invasion and metastasis by inhibiting the EMT of thyroid cancer cells. In addition, the prognostic value of TSHR in thyroid cancer was analyzed. Immunohistochemical analysis of 172 DTC tissues revealed that a lack of expression of TSHR was associated with distant metastasis and a poor survival rate. Multivariate analyses demonstrated that TSHR expression was a significant prognostic factor for distant metastasis and survival time. The results from the present study demonstrated that TSHR inhibits metastasis through regulating EMT , and that a lack of expression of TSHR is a significant independent factor affecting distant metastasis and poor prognosis in DTC.
在分化型甲状腺癌（DTC）中，促甲状腺激素受体（TSHR）与转移之间的关联以及潜在的分子机制仍不清楚。据我们所知，TSHR在上皮-间质转化（EMT）中的作用尚未见报道。在本研究中，我们探究了TSHR在DTC远处转移中的作用。TSHR在高分化甲状腺癌细胞和组织中显著下调，TSHR的缺失通过抑制甲状腺癌细胞的EMT促进了甲状腺癌细胞的侵袭和转移。此外，我们分析了TSHR在甲状腺癌中的预后价值。对172例DTC组织进行免疫组化分析发现，TSHR表达缺失与远处转移及低生存率相关。多因素分析表明，TSHR表达是远处转移和生存时间的一个重要预后因素。本研究结果表明，TSHR通过调节EMT抑制转移，TSHR表达缺失是影响DTC远处转移和不良预后的一个重要独立因素。
