Zhang Shuang, Shao Qiqi, Geng Haiyang, Su Songkun
College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P.R. China.
College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P.R. China.
Oncol Lett. 2017 Dec;14(6):7615-7621. doi: 10.3892/ol.2017.7078. Epub 2017 Sep 27.
Due to various pharmacological properties, including antioxidative, anti-inflammatory and antibiotic properties, royal jelly (RJ) has been widely consumed in daily diets in numerous countries. In the present study, the effect of RJ on 4T1-bearing mice was investigated. The study was performed by feeding 4T1-bearing mice with RJ using either the prophylactic-therapeutic (PTRJ) or therapeutic (TRJ) method. The experimental results for the PTRJ group demonstrated that the weight of tumor was significantly reduced (RJ 0.5 and 1.5 g/kg); and in the serum, the levels of interleukin (IL)-2 (RJ 0.5 and 1.5 g/kg), interferon (IFN)-α, superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) were significantly elevated, but the concentrations of IL-4 (RJ 0.5 and 1.5 g/kg) and IL-10 (RJ 1.0 g/kg) were significantly decreased. In addition, the activities of T-AOC and glutathione reductase (GR) were significantly improved in the liver, whereas in the kidney, the activities of T-AOC and GR were significantly increased only under the dose of 0.5 g/kg. For the TRJ group, the antitumor effect of RJ was not significant; the change in IL-2, IFN-α, SOD and T-AOC levels in the serum, and the change in T-AOC and GR in liver were similar to those observed in the PTRJ groups. RJ treatment was demonstrated to reduce the development of breast tumor in mice, and simultaneously improve the antioxidant capacity of the serum, liver and kidney, particularly using the prophylactic-therapeutic method. These results corroborated the efficacy of RJ supplementation in diets. The results of the present study suggest that the antioxidant and immunomodulatory activities of RJ serve an important role on antitumor growth.
由于蜂王浆（RJ）具有多种药理特性，包括抗氧化、抗炎和抗菌特性，在许多国家它已被广泛用于日常饮食中。在本研究中，研究了RJ对携带4T1肿瘤的小鼠的影响。该研究通过采用预防性-治疗性（PTRJ）或治疗性（TRJ）方法给携带4T1肿瘤的小鼠喂食RJ来进行。PTRJ组的实验结果表明，肿瘤重量显著减轻（RJ剂量为0.5和1.5 g/kg）；血清中白细胞介素（IL）-2（RJ剂量为0.5和1.5 g/kg）、干扰素（IFN）-α、超氧化物歧化酶（SOD）和总抗氧化能力（T-AOC）水平显著升高，但IL-4（RJ剂量为0.5和1.5 g/kg）和IL-10（RJ剂量为1.0 g/kg）浓度显著降低。此外，肝脏中T-AOC和谷胱甘肽还原酶（GR）的活性显著提高，而在肾脏中，仅在0.5 g/kg剂量下T-AOC和GR的活性显著增加。对于TRJ组，RJ的抗肿瘤作用不显著；血清中IL-2、IFN-α、SOD和T-AOC水平的变化，以及肝脏中T-AOC和GR的变化与PTRJ组观察到的相似。已证明RJ治疗可减少小鼠乳腺肿瘤的发生，同时提高血清、肝脏和肾脏的抗氧化能力，特别是采用预防性-治疗性方法时。这些结果证实了在饮食中补充RJ的有效性。本研究结果表明，RJ的抗氧化和免疫调节活性在抗肿瘤生长中起重要作用。
