Wei Meng-Meng, Wang Shuang-Shuang, Zheng Jia-Lu, Chen Jin-Jun, Yan Xia, An Hong-Mei, Hu Bing
Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China.
Institute of Traditional Chinese Medicine in Oncology, Shanghai Academy of Traditional Chinese Medicine, Shanghai 200032, P.R. China.
Oncol Lett. 2017 Dec;14(6):7767-7772. doi: 10.3892/ol.2017.7206. Epub 2017 Oct 18.
Metastasis is one of the primary obstacles to the successful treatment of colorectal cancer. Teng-Long-Bu-Zhong-Tang (TLBZT) is a modern Chinese herbal formula that may be useful in the treatment of metastatic colorectal cancer. The present study evaluated the effects of TLBZT on lung metastasis in human RKO colon carcinoma cells injected into mice via the tail vein. The results demonstrated that TLBZT inhibited the metastasis of human RKO colon carcinoma cells to the lungs. TLBZT downregulated the expression of LOX and hypoxia-inducible factor 1α. TLBZT also inhibited the expression of integrins αV and β3 and the phosphorylation of focal adhesion kinase. These results indicate that TLBZT inhibits the lung metastasis of RKO colon carcinoma by regulating the expression of multiple genes. The results of the present study provide a new basis for the management of colorectal cancer metastasis using treatments derived from Chinese herbs.
转移是结直肠癌成功治疗的主要障碍之一。腾龙补中汤（TLBZT）是一种现代中药配方，可能对转移性结直肠癌的治疗有用。本研究评估了TLBZT对通过尾静脉注射到小鼠体内的人RKO结肠癌细胞肺转移的影响。结果表明，TLBZT抑制人RKO结肠癌细胞向肺部的转移。TLBZT下调了赖氨氧化酶（LOX）和缺氧诱导因子1α的表达。TLBZT还抑制了整合素αV和β3的表达以及粘着斑激酶的磷酸化。这些结果表明，TLBZT通过调节多个基因的表达来抑制RKO结肠癌的肺转移。本研究结果为使用中药衍生疗法治疗结直肠癌转移提供了新的依据。
