Leslie D F, Greenway H T
Department of Dermatology, Scripps Clinic and Research Foundation, La Jolla, California.
Australas J Dermatol. 1991;32(3):159-64. doi: 10.1111/j.1440-0960.1991.tb01783.x.
Mohs Micrographic Surgery is a technique offering superior treatment for skin cancer with cure rates of 99% for primary and 94.4% for recurrent BCC, greater than 94% for SCC. As developed by Dr Frederic Mohs, the technique originally involved application of a chemical fixative. Mohs' fresh tissue technique is now usual, with immediate horizontal frozen sectioning of the entire margins of excised tissue, mapping and microscopic identification of remaining tumour, then repeat excisions, mapping and examination until a tumour-free plane is demonstrated throughout. This provides maximal conservation of uninvolved tissue structures, and allows more confident repair of a cancer-free surgical defect. Mohs Micrographic Surgery is becoming more widely available in Australasia; concurrently, indications for the technique are widening, as are the research interests, training opportunities, and professional organization of Mohs Practitioners. Very high, and increasing, incidence and prevalence of skin cancer in Australasia, and factors tending to contribute to this, suggest that Mohs Micrographic Surgery has an expanding role to play in Australasia.
莫氏显微外科手术是一种为皮肤癌提供卓越治疗效果的技术,原发性基底细胞癌的治愈率为99%,复发性基底细胞癌的治愈率为94.4%,鳞状细胞癌的治愈率超过94%。由弗雷德里克·莫氏医生所开创,该技术最初涉及应用一种化学固定剂。如今常用的是莫氏新鲜组织技术,即对切除组织的整个边缘立即进行水平冰冻切片,绘制图谱并在显微镜下识别残留肿瘤,然后重复切除、绘制图谱和检查,直至整个切除平面无肿瘤显示。这能最大程度地保留未受累的组织结构,并使无癌手术缺损的修复更可靠。莫氏显微外科手术在澳大拉西亚地区越来越普及;与此同时,该技术的适应证在拓宽,莫氏手术从业者的研究兴趣、培训机会和专业组织也在增加。澳大拉西亚地区皮肤癌的发病率和患病率非常高且呈上升趋势以及导致这种情况的因素表明,莫氏显微外科手术在澳大拉西亚地区将发挥越来越大的作用。