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本文引用的文献

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Increased Tear Fluid Production as a Compensatory Response to Meibomian Gland Loss: A Multicenter Cross-sectional Study.泪液分泌增加作为麦氏腺缺失的代偿反应：一项多中心横断面研究。
Ophthalmology. 2015 May;122(5):925-33. doi: 10.1016/j.ophtha.2014.12.018. Epub 2015 Jan 24.
2
Artificial tears potpourri: a literature review.人工泪液杂谈：文献综述
Clin Ophthalmol. 2014 Jul 31;8:1419-33. doi: 10.2147/OPTH.S65263. eCollection 2014.
3
Establishment of the mild, moderate and severe dry eye models using three methods in rabbits.采用三种方法建立兔的轻度、中度和重度干眼模型。
BMC Ophthalmol. 2013 Oct 5;13:50. doi: 10.1186/1471-2415-13-50.
4
Establishment of a rabbit model for keratoconjunctivitis sicca.建立干燥性角膜结膜炎的兔模型。
Cornea. 2011 Sep;30(9):1024-9. doi: 10.1097/ICO.0b013e3181f1b0fc.
5
Histomorphology of the Harderian gland in the Angora rabbit.安哥拉兔哈德氏腺的组织形态学
Anat Histol Embryol. 2010 Dec;39(6):494-502. doi: 10.1111/j.1439-0264.2010.01020.x.
6
"A new lachrymal gland with an excretory duct in red and fallow deer" by Johann jacob Harder (1694): English translation and historical perspective.约翰·雅各布·哈德（1694 年）所著《赤鹿和黇鹿中带有排泄管的新泪腺》：英文翻译及历史视角
Ann Anat. 2007;189(5):423-33. doi: 10.1016/j.aanat.2006.10.008.
7
Animal models of dry eye: a critical assessment of opportunities and limitations.干眼的动物模型：对机遇与局限的批判性评估
Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1641-6. doi: 10.1167/iovs.03-1055.
8
Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3-diacylglycerol.油酰辅酶A是硬脂酰辅酶A去饱和酶1基因亚型的主要从头合成产物，也是哈德氏腺1-烷基-2,3-二酰甘油生物合成的底物。
J Biol Chem. 2001 Oct 19;276(42):39455-61. doi: 10.1074/jbc.M106442200. Epub 2001 Aug 10.
9
A new rabbit model for keratoconjunctivitis sicca.一种新型的干眼症兔模型。
Invest Ophthalmol Vis Sci. 1987 Feb;28(2):225-8.
10
The harderian gland: a tercentennial review.哈德氏腺：三百周年回顾
J Anat. 1994 Aug;185 ( Pt 1)(Pt 1):1-49.

通过选择性切除哈德氏腺、泪腺和睑板腺建立“大眼”手术诱导干眼兔模型的初步研究。

Pilot Study of a "Large-Eye," Surgically Induced Dry Eye Rabbit Model by Selective Removal of the Harderian, Lacrimal, and Meibomian Glands.

作者信息

Polans Arthur S, McAnulty Jonathan F, Phelps Paul O, Darjatmoko Soesiawati R, Burris Christopher K, Albert Daniel M

机构信息

Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI.

McPherson Eye Research Institute, University of Wisconsin, Madison, WI.

出版信息

Ocul Oncol Pathol. 2017 Dec;4(1):52-56. doi: 10.1159/000475994. Epub 2017 Jul 19.

DOI:10.1159/000475994
PMID:29344500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5757560/
Abstract

BACKGROUND/AIMS: Establish a reliable rabbit dry eye (DE) model.

METHODS

An interventional cohort study surgically removing glands contributing to the tear film. Eight rabbits were studied after removal of left lacrimal, Harderian, or both glands. Additional rabbits had Meibomian glands in the left eye thermally obstructed. All were followed for 10 weeks with phenol red thread (PRT) and slit-lamp examination with 2% fluorescein. We assessed corneal sensitivity using a Cochet-Bonnet esthesiometer. Outcome measures were severity/duration of reduced PRT, punctate epithelial erosions (PEE), and histologic evidence of corneal pannus.

RESULTS

Fluorescein staining demonstrated signs of dryness including PEE in all of the interventional eyes. The subjective measurement of epithelial erosions correlated with decreased tear production. PRT measurements in the control eyes averaged 31.54 mm (±1.83) and 22.71 mm (±1.60) in the eight left eyes, without loss of corneal sensitivity.

CONCLUSIONS

Surgical removal of either the Harderian or lacrimal gland results in statistically significant decreases in tear volume and the development of severe DE. Removal of both glands results in the occurrence of a DE of comparable severity/duration to removal of either the lacrimal or Harderian gland alone. Meibomian gland obstruction contributes less to the DE model.

摘要

背景/目的：建立一种可靠的兔干眼模型。

方法

一项干预性队列研究，通过手术切除对泪膜有贡献的腺体。八只兔子在切除左侧泪腺、副泪腺或两者后接受研究。另外的兔子左眼睑板腺受到热阻塞。所有兔子均用酚红棉线（PRT）随访10周，并使用2%荧光素进行裂隙灯检查。我们使用Cochet-Bonnet眼压计评估角膜敏感性。观察指标为PRT缩短的严重程度/持续时间、点状上皮糜烂（PEE）以及角膜血管翳的组织学证据。

结果

荧光素染色显示所有干预眼均有干眼迹象，包括PEE。上皮糜烂的主观测量结果与泪液分泌减少相关。对照组眼睛的PRT测量值，八只左眼平均为31.54毫米（±1.83），且角膜敏感性未丧失。

结论

手术切除副泪腺或泪腺会导致泪液量在统计学上显著减少，并出现严重干眼。切除两者导致的干眼严重程度/持续时间与单独切除泪腺或副泪腺相当。睑板腺阻塞对干眼模型的影响较小。