Gilbard J P, Rossi S R, Gray K L
Eye Research Institute of Retina Foundation, Boston, MA 02114, USA.
Invest Ophthalmol Vis Sci. 1987 Feb;28(2):225-8.
The authors created a new rabbit model for keratoconjunctivitis sicca by cauterizing the lacrimal gland excretory duct and surgically removing the nictitating membrane and harderian gland. Although the slit-lamp examination findings remained normal for the first 8 wk postoperatively, tear-film osmolarity was elevated by postoperative day 1. Corneal epithelial glycogen levels declined progressively, and conjunctival goblet cell density remained decreased. Multiple controls indicated that closure of the lacrimal gland excretory duct was required for elevation of tear film osmolarity, which, in turn, was required for persistent ocular surface disease.
作者通过烧灼泪腺排泄管并手术切除瞬膜和哈德氏腺，创建了一种新的兔干角结膜炎模型。尽管术后前8周裂隙灯检查结果仍正常，但术后第1天泪膜渗透压就升高了。角膜上皮糖原水平逐渐下降，结膜杯状细胞密度持续降低。多项对照表明，泪膜渗透压升高需要封闭泪腺排泄管，而持续性眼表疾病则需要泪膜渗透压升高。
