Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
Department of Material Chemistry, Graduate School of Engineering, Kyoto University , Nishikyo-ku, Kyoto 615-8510, Japan.
J Am Chem Soc. 2018 Jan 31;140(4):1243-1246. doi: 10.1021/jacs.7b12864. Epub 2018 Jan 22.
This report details a new method for site-selective methylene oxidation adjacent to azaheterocycles. A dual catalysis approach, utilizing both an iron Lewis acid and an organic hydroxylamine catalyst, proved highly effective. We demonstrate that this method provides complementary selectivity to other known catalytic approaches and represents an improvement over current heterocycle-selective reactions that rely on stoichiometric activation.
本报告详细介绍了一种新的方法，用于在氮杂环邻位选择性地进行亚甲基氧化。双催化方法，同时利用铁路易斯酸和有机羟胺催化剂，被证明非常有效。我们证明，这种方法提供了对其他已知催化方法的补充选择性，并且优于目前依赖于化学计量激活的杂环选择性反应。
