Li Tianlei, Li Jishun, Zhu Zihao, Pan Weidong, Wu Song
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing 100005 China
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medcial University Guiyang 550014 China
RSC Adv. 2019 Jul 4;9(36):20879-20883. doi: 10.1039/c9ra03346g. eCollection 2019 Jul 1.
A cobalt-catalyzed C(sp)-H oxygenation reaction to furnish aldehyde was herein reported. This transformation demonstrated high chemo-selectivity, and tolerated various methylarenes bearing electron-withdrawing substituents. This reaction provided rapid access to diverse aldehydes form methylarenes. Notably, TFA/TFAA was used for the first time as a mixed solvent in cobalt-catalyzed oxygenation of benzylic methylenes.
本文报道了一种钴催化的C(sp)-H氧化反应以制备醛。该转化表现出高化学选择性，并且能耐受各种带有吸电子取代基的甲基芳烃。该反应能从甲基芳烃快速获得多种醛。值得注意的是，三氟乙酸/三氟乙酸酐首次被用作钴催化苄基亚甲基氧化反应的混合溶剂。
