Chi Quanbo, Wang Guoyi, Sheng Yao, Xu Wentao, Shi Pengfei, Zhao Changhui, Huang Kunlun
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Department of Food and Bioengineering, Beijing Vocational College of Agriculture, Beijing, China.
Int J Med Mushrooms. 2017;19(11):1001-1008. doi: 10.1615/IntJMedMushrooms.2017024486.
Pleurotus citrinopileatus is an edible medicinal mushroom rich in biomolecules and thus has a high potential for use in formulating pharmaceutical and nutraceutical products. To test its effect on body weight and glucose control, we generated diet-induced obese (DIO) C57BL/6J male mice by feeding the mice a high-fat diet (60% fat) for 8 weeks and treating them with an ethanolic P. citrinopileatus extract (PCE) at either 200 or 500 mg/kg body weight for 12 additional weeks. The results showed that PCE significantly inhibited high-fat diet-induced weight gain, fat accumulation, and glucose intolerance in the DIO mice. Moreover, the PCE had a beneficial effect on liver and kidney function. On the basis of these results, we conclude that PCE is effective in the treatment of metabolic syndrome and thus could be a good candidate for use in future pharmaceutical or nutraceutical applications.
金顶侧耳是一种富含生物分子的可食用药用蘑菇，因此在制药和营养保健品配方中具有很高的应用潜力。为了测试其对体重和血糖控制的影响，我们通过给小鼠喂食高脂肪饮食（60%脂肪）8周，然后再用体重200或500 mg/kg的金顶侧耳乙醇提取物（PCE）处理12周，构建了饮食诱导肥胖（DIO）的C57BL/6J雄性小鼠。结果表明，PCE显著抑制了DIO小鼠中由高脂肪饮食引起的体重增加、脂肪堆积和葡萄糖不耐受。此外，PCE对肝脏和肾脏功能有有益影响。基于这些结果，我们得出结论，PCE在代谢综合征的治疗中有效，因此可能是未来制药或营养保健品应用的良好候选物。
