Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Nutrients. 2022 Apr 29;14(9):1868. doi: 10.3390/nu14091868.
(PO), a common edible mushroom, contains rich nutritional components with medicinal properties. To explore the effect of PO on ameliorating obesity and modulating the gut microbiota, we administered the mice with a low-fat diet or high-fat diet containing different dosages of PO (mass fraction: 0%, 2.5%, 5% and 10%). The body weight, adipose tissue weight, GTT, ITT, blood lipids, serum biomarkers of liver/kidney function, the gut microbiota and function were measured and analyzed after 6 weeks of PO treatment. The results showed PO prevented obesity, maintained glucose homeostasis and beneficially modulated gut microbiota. PO modified the composition and functions of gut microbiota in obese mice and make them similar to those in lean mice, which contributed to weight loss. PO significantly increased the relative abundance of , group and , while decreased the relative abundance of and . The prediction of gut microbiota function showed PO upregulated lipid metabolism, carbohydrate metabolism, bile acid biosynthesis, while it downregulated adipocytokine signaling pathway and steroid hormone biosynthesis. Correlation analysis further suggested the potential relationship among obesity, gut microbiota and the function of gut microbiota. In conclusion, all the results indicated that PO ameliorated obesity at least partly by modulating the gut microbiota.
（PO），一种常见的食用蘑菇，含有丰富的营养成分和药用特性。为了探究 PO 改善肥胖和调节肠道微生物群的作用，我们给小鼠喂食低脂肪饮食或高脂肪饮食，并添加不同剂量的 PO（质量分数：0%、2.5%、5%和 10%）。经过 6 周的 PO 处理后，测量和分析了小鼠的体重、脂肪组织重量、GTT、ITT、血脂、肝/肾功能的血清生物标志物、肠道微生物群和功能。结果表明，PO 可预防肥胖、维持葡萄糖稳态并有益地调节肠道微生物群。PO 改变了肥胖小鼠肠道微生物群的组成和功能，使其类似于瘦小鼠，从而有助于减肥。PO 显著增加了 、 和 的相对丰度，而降低了 和 的相对丰度。肠道微生物群功能的预测表明，PO 上调了脂代谢、碳水化合物代谢、胆汁酸生物合成，同时下调了脂肪细胞因子信号通路和类固醇激素生物合成。相关性分析进一步表明肥胖、肠道微生物群和肠道微生物群功能之间存在潜在的关系。总之，所有结果表明，PO 通过调节肠道微生物群至少部分改善了肥胖。
