Fazakas-Todea I, Checiu M, Sandor S
Morphol Embryol (Bucur). 1985 Oct-Dec;31(4):249-56.
The effects of chronic consumption of some beverages (plum-brandy 24% and cognac 20%) upon preimplantation development in rats were studied. The control of possible effects was performed on day 5 by usual flushing, examination and photographying of oviductal and uterine embryos. In order to evaluate the effect of the beverage applied, the following criteria were used: mean litter size, migration of the embryos from the oviduct to the uterus, the developmental stage attained by the pre-implantation embryos and the appearance of pathological embryos. The main results were the following: both beverages applied influenced the preimplantation development; with respect to the developmental rate and to the induction of pathological changes, the effect of both beverages was similar (retardation and an increased, number of pathological morulae and blastocysts); a different action could be detected as to the mean litter size and to the migration of preimplantation embryos: plum-brandy reduced more substantially the mean litter size, whereas cognac had a more marked retarding effect upon the migration of embryos from the oviduct to the uterus: all the changes detected show a more or less marked "litter-effect". The present data were compared with the corresponding effects of chronic ethanol administration observed previously in our laboratory. No obvious potentiating effect of beverage congeners could be established. The findings are discussed in connection with other experimental models of alcohol embryo and fetopathy.
研究了长期饮用某些饮料（24%的李子白兰地和20%的干邑白兰地）对大鼠植入前发育的影响。在第5天通过常规冲洗、检查和拍摄输卵管及子宫内的胚胎来控制可能的影响。为了评估所应用饮料的效果，采用了以下标准：平均窝仔数、胚胎从输卵管向子宫的迁移、植入前胚胎达到的发育阶段以及病理性胚胎的出现。主要结果如下：两种饮料均影响植入前发育；就发育速率和病理性变化的诱导而言，两种饮料的效果相似（发育迟缓以及病理性桑椹胚和囊胚数量增加）；在平均窝仔数和植入前胚胎的迁移方面可检测到不同的作用：李子白兰地更显著地降低了平均窝仔数，而干邑白兰地对胚胎从输卵管向子宫的迁移有更明显的延缓作用：所有检测到的变化都或多或少显示出明显的“窝仔效应”。将目前的数据与我们实验室先前观察到的慢性乙醇给药的相应效果进行了比较。未发现饮料同系物有明显的增强作用。结合酒精胚胎病和胎儿病的其他实验模型对这些发现进行了讨论。
