Fazakaş-Todea I
Laboratory of Embryology, Center of Hygiene and Public Health, Timişoara, Romania.
Rom J Morphol Embryol. 1993 Jan-Jun;39(1-2):27-32.
The effect of acute preimplantation intoxication with beer and cognac, on the background of chronic biparental consumption, was investigated in mice (controlled on day 4 of pregnancy), by using the following criteria: mean number of embryos/animal; oviductal-uterine migration of embryos; developmental rate; number of pathologically modified embryos. It resulted that both beverages used have a noxious effect upon preimplantation development, producing: retardation of oviductal-uterine migration and the increase of the number of pathologically modified embryos. Although the experimental model applied represents a maximal schedule of beverage administration (chronic biparental + acute), the effects were not enhanced as compared with previous results obtained by a less "forced" administration (chronic maternal + acute).
在小鼠（于妊娠第4天进行对照）中，研究了在双亲长期饮酒的背景下，急性摄入啤酒和干邑白兰地对植入前胚胎的影响，采用了以下标准：平均每只动物的胚胎数；胚胎在输卵管 - 子宫的迁移情况；发育率；病理改变胚胎的数量。结果表明，所使用的两种饮品对植入前胚胎发育均有有害影响，表现为：输卵管 - 子宫迁移延迟以及病理改变胚胎数量增加。尽管所应用的实验模型代表了饮品给药的最大剂量方案（双亲长期 + 急性），但与之前通过较“温和”给药方式（母体长期 + 急性）获得的结果相比，其影响并未增强。
