Checiu M
Laboratory of Embryology and Teratology, Institute of Public Health and Medical Research, Timişoara, Romania.
Rom J Morphol Embryol. 1993 Jan-Jun;39(1-2):21-5.
The effect of chronic biparental alcoholization upon preimplantation rat embryos was investigated. On day 5 of pregnancy the following were controlled: developmental stage attained; mean number of embryos/animal; mean number of cells/embryo; mean number of cells/blastocyst; mean number of cells/early blastocyst; oviductal-uterine migration rate and the number of pathological embryos. Chronic biparental alcoholization induced a delay of the onset of cavitation and a significantly increased number of pathological embryos. Chronic biparental alcoholization has a more marked effect than chronic maternal alcoholization. In mice (RAP strain), the same experimental schedule induced more marked effects than in rats.
研究了慢性双亲酒精化对植入前大鼠胚胎的影响。在妊娠第5天，对以下指标进行了控制：达到的发育阶段；每只动物的胚胎平均数；每个胚胎的细胞平均数；每个囊胚的细胞平均数；每个早期囊胚的细胞平均数；输卵管-子宫迁移率以及病理胚胎数。慢性双亲酒精化导致空泡形成起始延迟，病理胚胎数显著增加。慢性双亲酒精化的影响比慢性母体酒精化更为明显。在小鼠（RAP品系）中，相同的实验方案所产生的影响比大鼠更为显著。
