Shah Abdus Saboor, Khan Shahzeb, Rahim Haroon, Chishti Kamran Ahmad, Khan Aamir Ghafoor
Department of Pharmacy, University of Malakand, Malakand, Pakistan.
Department of Pharmacy, Sarhard University of Science and Technology, Peshawar, Pakistan.
Pak J Pharm Sci. 2018 Jan;31(1):193-198.
Non-alcoholic fatty liver disease prevalence has not been well established. The aims of this study was to define prospectively non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD) prevalence in hospitalized and ambulatory patients 20-65 years old during June 2013 to June 2014 were selected from Combined Military Hospital Peshawar Cantonment area. A base line questionnaire and right upper quadrant ultrasound was completed by all patients. On identifications of fatty liver among the selected cases further lab test data and liver biopsy reports were obtained. Mean BMI of female was 29.9 + 5.65 while prevalence of hypertension and diabetes was 49.8% and 16.6% respectively. Among all patients 62% were Punjabies, 23% were Pathans while 12% were Sindhies. Overall NAFLD prevalence was 47% while NASH was confirmed in 20 patients (12.3% of total and 30%of ultrasound positive patients). Pathans had the highest prevalence of NAFLD (58.5%) as compared to Punjabies (44.5%) and Sindhies (35.3%). Pathans also had a higher prevalence of NASH compared with Punjabies (19.5% VS 10%: P= 0.03). In general, NAFLD patients were more prevalent among male (59%), Diabetic (P<0.00005), hypertensive (P<0.00005) and older (P =0.005). They consumed more fast food (P=.049) had a higher BMI (P<0.0005) and had little or no exercise as compared to their normal or non NAFLD counter parts (P=0.02). NAFLD was found in 75% and NASH in 22.5% among the 26 diabetic patients. ALT, AST, BMI, insulin, quantitative insulin sensitivity checks index and cytokeratin - 18 correlated with NASH. It was concluded that NAFLD and NASH prevalence is higher than estimated previously, Pathans and Patients with diabetes are at high risk.
非酒精性脂肪性肝病的患病率尚未完全明确。本研究的目的是前瞻性地确定2013年6月至2014年6月期间白沙瓦军区联合军事医院20至65岁住院及门诊患者中非酒精性脂肪性肝炎（NASH）和非酒精性脂肪性肝病（NAFLD）的患病率。所有患者均完成了基线问卷调查和右上腹超声检查。在选定病例中确诊为脂肪肝后，进一步获取实验室检查数据和肝活检报告。女性的平均体重指数为29.9±5.65，高血压和糖尿病的患病率分别为49.8%和16.6%。在所有患者中，旁遮普人占62%，普什图人占23%，信德人占12%。总体NAFLD患病率为47%，20例患者确诊为NASH（占总数的12.3%，超声检查阳性患者的30%）。与旁遮普人（44.5%）和信德人（35.3%）相比，普什图人的NAFLD患病率最高（58.5%）。普什图人的NASH患病率也高于旁遮普人（19.5%对10%：P=0.03）。总体而言，NAFLD患者在男性（59%）、糖尿病患者（P<0.00005）、高血压患者（P<0.00005）和老年人（P=0.005）中更为普遍。与正常或非NAFLD患者相比，他们食用更多快餐（P=0.049）、体重指数更高（P<0.0005）且很少或不运动（P=0.02）。26例糖尿病患者中，NAFLD患病率为75%，NASH患病率为22.5%。谷丙转氨酶、谷草转氨酶、体重指数、胰岛素、定量胰岛素敏感性检查指数和细胞角蛋白-18与NASH相关。研究得出结论，NAFLD和NASH的患病率高于先前估计，普什图人和糖尿病患者处于高风险状态。
