Division of Gastroenterology and Hepatology, Department of Medicine, San Antonio Military Medical Center, Fort Sam Houston, TX, USA.
Aliment Pharmacol Ther. 2015 Feb;41(3):293-300. doi: 10.1111/apt.13042. Epub 2014 Dec 18.
Psoriasis has been linked to metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Data suggest that the prevalence of NAFLD is increased in patients with psoriasis. The aim of this study was to determine the prevalence and severity of NAFLD in this patient population.
To determine the prevalence of both NAFLD and non-alcoholic steatohepatitis (NASH) in patients with psoriasis.
Patients between the ages of 18 and 70 years with a diagnosis of psoriasis or psoriatic arthritis and followed by either the Dermatology or Rheumatology Division within the Department of Medicine at San Antonio Military Medical Center were considered for enrollment. Each patient completed a questionnaire, underwent a thorough skin evaluation, and had a right upper quadrant ultrasound and fasting blood work. If the liver enzymes were elevated or fatty liver detected on imaging, percutaneous liver biopsy was recommended.
One hundred and twenty-nine patients were enrolled and 103 completed all necessary studies. The participants were predominantly middle aged (52.7 ± 12) and overweight or obese (average BMI 30.1 ± 5.9, range: 19.8-52.5 kg/m(2)). 53% (n = 54) were male while 15% (n = 15) of participants identified themselves as being a diabetic. The overall prevalence of NAFLD was 47%. The overall prevalence of NASH was 22% in those who underwent biopsy.
Non-alcoholic fatty liver disease is very common among our cohort of patients with psoriasis, occurring in roughly 47% of patients. The more progressive form of the disease, NASH, is found in approximately one in five patients. Health care providers should be mindful of this association given the high prevalence of both NAFLD and NASH in this cohort of patients.
银屑病与代谢综合征和非酒精性脂肪性肝病（NAFLD）有关。有数据表明，银屑病患者的 NAFLD 患病率增加。本研究旨在确定该患者人群中 NAFLD 的患病率和严重程度。
确定患有银屑病的患者中 NAFLD 和非酒精性脂肪性肝炎（NASH）的患病率。
年龄在 18 至 70 岁之间，被诊断为银屑病或银屑病关节炎，并在圣安东尼奥军事医疗中心医学系皮肤科或风湿病科接受治疗的患者被认为符合入组条件。每位患者完成一份问卷，接受全面的皮肤评估，并进行右季肋区超声和空腹血液检查。如果肝酶升高或影像学检查提示脂肪肝，则建议进行经皮肝活检。
共纳入 129 例患者，其中 103 例完成了所有必要的研究。参与者主要为中年人（52.7 ± 12 岁），超重或肥胖（平均 BMI 为 30.1 ± 5.9，范围为 19.8-52.5kg/m²）。53%（n = 54）为男性，15%（n = 15）的参与者为糖尿病患者。NAFLD 的总体患病率为 47%。接受活检的患者中，NASH 的总体患病率为 22%。
在我们的银屑病患者队列中，非酒精性脂肪性肝病非常常见，约有 47%的患者患有该病。在大约五分之一的患者中发现了更具进展性的疾病 NASH。鉴于该患者队列中 NAFLD 和 NASH 的高患病率，医疗保健提供者应该注意到这种关联。
