Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Cambridge, UK.
Centre de Physiopathologie Toulouse-Purpan, INSERM UMR1043/CNRS U5282, Toulouse, France.
Nat Immunol. 2018 Feb;19(2):120-129. doi: 10.1038/s41590-017-0028-4. Epub 2018 Jan 18.
RNA-binding proteins (RBPs) are essential for the development and function of the immune system. They interact dynamically with RNA to control its biogenesis and turnover by transcription-dependent and transcription-independent mechanisms. In this Review, we discuss the molecular mechanisms by which RBPs allow gene expression changes to occur at different speeds and to varying degrees, and which RBPs regulate the diversity of the transcriptome and proteome. These proteins are nodes for integration of transcriptional and signaling networks and are intimately linked to intermediary metabolism. They are essential components of regulatory feedback mechanisms that maintain immune tolerance and limit inflammation. The role of RBPs in malignancy and autoimmunity has led to their emergence as targets for the development of new therapeutic modalities.
RNA 结合蛋白（RBPs）对于免疫系统的发育和功能至关重要。它们通过依赖转录和非依赖转录的机制与 RNA 动态相互作用，以控制 RNA 的生物发生和周转。在这篇综述中，我们讨论了 RBPs 使基因表达以不同速度和不同程度发生变化的分子机制，以及哪些 RBPs 调节转录组和蛋白质组的多样性。这些蛋白质是整合转录和信号网络的节点，与中间代谢密切相关。它们是维持免疫耐受和限制炎症的调节反馈机制的重要组成部分。RBPs 在恶性肿瘤和自身免疫中的作用使其成为开发新治疗方法的靶点。
