• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

当归建中汤和当归芍药散预防绝经症状，且当归建中汤预防单碘乙酸诱导的骨关节炎的去卵巢肥胖大鼠的关节软骨退变。

Dangguijihwang-tang and Dangguijakyak-san Prevent Menopausal Symptoms and Dangguijihwang-tang Prevents Articular Cartilage Deterioration in Ovariectomized Obese Rats with Monoiodoacetate-Induced Osteoarthritis.

作者信息

Lee Hye Won, Ko Byung-Seob, Kang Suna, Ryuk Jin Ah, Kim Min Joo, Park Sunmin

机构信息

Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.

Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2017;2017:5658681. doi: 10.1155/2017/5658681. Epub 2017 Oct 24.

DOI:10.1155/2017/5658681
PMID:29348767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5733984/
Abstract

We investigated whether dangguijakyak-san (DJY) and dangguijihwang-tang (DJH), oriental medicines traditionally used for inflammatory diseases, could prevent and/or delay the progression of postmenopausal symptoms and osteoarthritis in osteoarthritis-induced estrogen-deficient rats. Treated ovariectomized (OVX) rats consumed either 1% DJY or 1% DJH in the diets. Positive-control rats were given 30 g/kg bw 17-estradiol and control rats were given 1% fat as were the normal-control rats. All rats received high-fat diets for 8 weeks. At the 9th week, OVX rats received articular injections of monoiodoacetate (MIA) or saline (normal control) into the right knee. At 3 weeks after MIA injection, DJY reduced visceral-fat mass and improved glucose metabolism by reducing insulin resistance, whereas DJH increased BMD and decreased insulin resistance. DJH improved weight distribution in the right knee and maximum running velocity on a treadmill at days 14 and 21 as much as those of the positive control. TNF-, IL-1, and IL-6 levels in articular cartilage were much higher in the control than the positive control, whereas both DJY and DJH reduced the levels to those of the positive control. The histological analysis assessed articular cartilage damage near the tidemark and proteoglycan loss in the control versus the positive control; DJY and DJH prevented this damage and proteoglycan loss. In conclusion, DJY may provide an effective treatment for improving glucose tolerance, and DJH may be appropriate for preventing osteoarthritis.

摘要

我们研究了传统上用于治疗炎症性疾病的东方药物当归芍药散（DJY）和当归地黄汤（DJH）是否可以预防和/或延缓骨关节炎诱导的雌激素缺乏大鼠绝经后症状和骨关节炎的进展。将处理过的去卵巢（OVX）大鼠在饮食中摄入1%的DJY或1%的DJH。阳性对照大鼠给予30 g/kg体重的17-β-雌二醇，对照大鼠给予1%的脂肪，与正常对照大鼠相同。所有大鼠接受高脂饮食8周。在第9周，OVX大鼠右膝接受单碘乙酸盐（MIA）或生理盐水（正常对照）关节注射。在MIA注射后3周，DJY通过降低胰岛素抵抗减少了内脏脂肪量并改善了葡萄糖代谢，而DJH增加了骨密度并降低了胰岛素抵抗。在第14天和第21天，DJH改善了右膝的重量分布和跑步机上的最大跑步速度，与阳性对照相当。对照组关节软骨中的肿瘤坏死因子-α、白细胞介素-1和白细胞介素-6水平远高于阳性对照组，而DJY和DJH均将这些水平降低至阳性对照组水平。组织学分析评估了对照与阳性对照中潮线附近的关节软骨损伤和蛋白聚糖损失；DJY和DJH预防了这种损伤和蛋白聚糖损失。总之，DJY可能为改善葡萄糖耐量提供有效的治疗方法，而DJH可能适合预防骨关节炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/f38093616426/ECAM2017-5658681.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/d8b871c8348e/ECAM2017-5658681.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/c9a9509177da/ECAM2017-5658681.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/be154d47eb47/ECAM2017-5658681.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/3b83d82bc171/ECAM2017-5658681.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/9f05695d13cd/ECAM2017-5658681.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/460995488029/ECAM2017-5658681.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/f38093616426/ECAM2017-5658681.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/d8b871c8348e/ECAM2017-5658681.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/c9a9509177da/ECAM2017-5658681.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/be154d47eb47/ECAM2017-5658681.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/3b83d82bc171/ECAM2017-5658681.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/9f05695d13cd/ECAM2017-5658681.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/460995488029/ECAM2017-5658681.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4517/5733984/f38093616426/ECAM2017-5658681.007.jpg

相似文献

1
Dangguijihwang-tang and Dangguijakyak-san Prevent Menopausal Symptoms and Dangguijihwang-tang Prevents Articular Cartilage Deterioration in Ovariectomized Obese Rats with Monoiodoacetate-Induced Osteoarthritis.当归建中汤和当归芍药散预防绝经症状，且当归建中汤预防单碘乙酸诱导的骨关节炎的去卵巢肥胖大鼠的关节软骨退变。
Evid Based Complement Alternat Med. 2017;2017:5658681. doi: 10.1155/2017/5658681. Epub 2017 Oct 24.
2
Asian Elm tree inner bark prevents articular cartilage deterioration in ovariectomized obese rats with monoiodoacetate-induced osteoarthritis.亚洲榆树内皮可预防单碘乙酸诱导的骨关节炎的去卵巢肥胖大鼠的关节软骨退化。
Menopause. 2016 Feb;23(2):197-208. doi: 10.1097/GME.0000000000000521.
3
Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats.姜黄素和四氢姜黄素均可预防雌激素缺乏大鼠的骨关节炎症状，并降低促炎细胞因子的表达。
Genes Nutr. 2016 Mar 17;11:2. doi: 10.1186/s12263-016-0520-4. eCollection 2016.
4
Rice Porridge Containing Welsh Onion Root Water Extract Alleviates Osteoarthritis-Related Pain Behaviors, Glucose Levels, and Bone Metabolism in Osteoarthritis-Induced Ovariectomized Rats.含葱白水提物的糙米粥可缓解骨关节炎诱导去卵巢大鼠的相关疼痛行为、血糖水平和骨代谢。
Nutrients. 2019 Jun 30;11(7):1503. doi: 10.3390/nu11071503.
5
Tetragonia tetragonioides (Pall.) Kuntze protects estrogen-deficient rats against disturbances of energy and glucose metabolism and decreases proinflammatory cytokines.番杏保护雌激素缺乏的大鼠免受能量和葡萄糖代谢紊乱的影响，并降低促炎细胞因子水平。
Exp Biol Med (Maywood). 2017 Mar;242(6):593-605. doi: 10.1177/1535370216683835. Epub 2016 Dec 13.
6
Aqueous Extracts of Root Bark and Fruit Protect against Osteoarthritis Symptoms in Testosterone-Deficient and Osteoarthritis-Induced Rats.根皮和果实的水提取物对睾酮缺乏和骨关节炎诱导大鼠的骨关节炎症状具有保护作用。
Pharmaceutics. 2020 Dec 21;12(12):1245. doi: 10.3390/pharmaceutics12121245.
7
The combination of Artemisia princeps Pamp, Leonurus japonicas Houtt, and Gardenia jasminoides Ellis fruit attenuates the exacerbation of energy, lipid, and glucose by increasing hepatic PGC-1α expression in estrogen-deficient rats.艾叶、益母草和栀子果实的组合通过增加雌激素缺乏大鼠肝脏中PGC-1α的表达来减轻能量、脂质和葡萄糖的恶化。
BMC Complement Altern Med. 2016 May 23;16:137. doi: 10.1186/s12906-016-1109-x.
8
Protection against Osteoarthritis Symptoms by Aerobic Exercise with a High-Protein Diet by Reducing Inflammation in a Testosterone-Deficient Animal Model.在睾酮缺乏动物模型中，通过有氧运动和高蛋白饮食减轻炎症来预防骨关节炎症状
Life (Basel). 2022 Jan 26;12(2):177. doi: 10.3390/life12020177.
9
Intraarticular injection of processed lipoaspirate cells has anti-inflammatory and analgesic effects but does not improve degenerative changes in murine monoiodoacetate-induced osteoarthritis.关节内注射经处理的脂肪抽吸细胞具有抗炎和镇痛作用，但不能改善单碘乙酸诱导的小鼠骨关节炎的退行性变化。
BMC Musculoskelet Disord. 2019 Jul 19;20(1):335. doi: 10.1186/s12891-019-2710-1.
10
Java Tea (Orthosiphon stamineus) protected against osteoarthritis by mitigating inflammation and cartilage degradation: a preclinical study.爪哇茶（Orthosiphon stamineus）通过减轻炎症和软骨降解来预防骨关节炎：一项临床前研究。
Inflammopharmacology. 2018 Aug;26(4):939-949. doi: 10.1007/s10787-017-0432-2. Epub 2018 Jan 29.

引用本文的文献

1
The Role of Sex Hormones in Cartilaginous Tissues: A Scoping Review.性激素在软骨组织中的作用：一项范围综述
JOR Spine. 2025 May 15;8(2):e70072. doi: 10.1002/jsp2.70072. eCollection 2025 Jun.
2
Chondroprotection and Molecular Mechanism of Action of Phytonutraceuticals on Osteoarthritis.植物营养素对骨关节炎的软骨保护作用及作用机制。
Molecules. 2021 Apr 20;26(8):2391. doi: 10.3390/molecules26082391.
3
Effects of herbal medicine ( for treating climacteric syndrome with a blood-deficiency-dominant pattern: A randomized, double-blind, placebo-controlled pilot trial.

本文引用的文献

1
Herbal medicine (Danggui Shaoyao San) for treating primary dysmenorrhea: A systematic review and meta-analysis of randomized controlled trials.治疗原发性痛经的草药（当归芍药散）：随机对照试验的系统评价和荟萃分析
Maturitas. 2016 Mar;85:19-26. doi: 10.1016/j.maturitas.2015.11.013. Epub 2015 Dec 2.
2
Decursin from Angelica gigas suppresses RANKL-induced osteoclast formation and bone loss.来自当归的紫花前胡素抑制RANKL诱导的破骨细胞形成和骨质流失。
Eur J Pharmacol. 2016 Mar 5;774:34-42. doi: 10.1016/j.ejphar.2016.01.008. Epub 2016 Jan 26.
3
Estrogens, inflammation and cognition.
中药治疗以血虚为主型更年期综合征的疗效：一项随机、双盲、安慰剂对照的试点试验。
Integr Med Res. 2021 Sep;10(3):100715. doi: 10.1016/j.imr.2021.100715. Epub 2021 Jan 9.
雌激素、炎症与认知。
Front Neuroendocrinol. 2016 Jan;40:87-100. doi: 10.1016/j.yfrne.2016.01.002. Epub 2016 Jan 12.
4
A systems pharmacology approach to decipher the mechanism of danggui-shaoyao-san decoction for the treatment of neurodegenerative diseases.一种用于解读当归芍药散治疗神经退行性疾病机制的系统药理学方法。
J Ethnopharmacol. 2016 Feb 3;178:66-81. doi: 10.1016/j.jep.2015.12.011. Epub 2015 Dec 8.
5
Response to diet-induced obesity produces time-dependent induction and progression of metabolic osteoarthritis in rat knees.对饮食诱导的肥胖的反应会导致大鼠膝关节代谢性骨关节炎随时间发生诱导和进展。
J Orthop Res. 2016 Jun;34(6):1010-8. doi: 10.1002/jor.23103. Epub 2015 Dec 2.
6
Asian Elm tree inner bark prevents articular cartilage deterioration in ovariectomized obese rats with monoiodoacetate-induced osteoarthritis.亚洲榆树内皮可预防单碘乙酸诱导的骨关节炎的去卵巢肥胖大鼠的关节软骨退化。
Menopause. 2016 Feb;23(2):197-208. doi: 10.1097/GME.0000000000000521.
7
Hand osteoarthritis, menopause and menopausal hormone therapy.手部骨关节炎、更年期与更年期激素疗法
Maturitas. 2016 Jan;83:13-8. doi: 10.1016/j.maturitas.2015.09.007. Epub 2015 Oct 1.
8
Estrogen receptor alpha and beta in health and disease.健康与疾病中的雌激素受体α和β
Best Pract Res Clin Endocrinol Metab. 2015 Aug;29(4):557-68. doi: 10.1016/j.beem.2015.04.008. Epub 2015 Apr 26.
9
Effect of selective estrogen receptor modulators on metabolic homeostasis.选择性雌激素受体调节剂对代谢稳态的影响。
Biochimie. 2016 May;124:92-97. doi: 10.1016/j.biochi.2015.06.018. Epub 2015 Jun 29.
10
Quantitative analysis of marker compounds in Angelica gigas, Angelica sinensis, and Angelica acutiloba by HPLC/DAD.采用高效液相色谱/二极管阵列检测器（HPLC/DAD）对当归、中国当归和细叶当归中的标记化合物进行定量分析。
Chem Pharm Bull (Tokyo). 2015;63(7):504-11. doi: 10.1248/cpb.c15-00081. Epub 2015 May 1.