Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Sci Adv. 2018 Jan 10;4(1):e1701427. doi: 10.1126/sciadv.1701427. eCollection 2018 Jan.
There is a replication crisis spreading through the annals of scientific inquiry. Although some work has been carried out to uncover the roots of this issue, much remains unanswered. With this in mind, this paper investigates how the gender of the experimenter may affect experimental findings. Clinical trials are regularly carried out without any report of the experimenter's gender and with dubious knowledge of its influence. Consequently, significant biases caused by the experimenter's gender may lead researchers to conclude that therapeutics or other interventions are either overtreating or undertreating a variety of conditions. Bearing this in mind, this policy paper emphasizes the importance of reporting and controlling for experimenter gender in future research. As backdrop, it explores what we know about the role of experimenter gender in influencing laboratory results, suggests possible mechanisms, and suggests future areas of inquiry.
目前,科学研究领域正面临着一场复制危机。尽管已经开展了一些工作来揭示这个问题的根源,但仍有许多问题没有得到解答。有鉴于此,本文探讨了实验者的性别如何影响实验结果。临床试验经常在没有报告实验者性别的情况下进行,而且对其影响也知之甚少。因此,由于实验者的性别而产生的重大偏差可能导致研究人员得出结论,认为治疗方法或其他干预措施对各种情况要么过度治疗,要么治疗不足。有鉴于此,本政策文件强调了在未来研究中报告和控制实验者性别的重要性。作为背景,本文探讨了我们对实验者性别在影响实验室结果方面的作用的了解,提出了可能的机制,并提出了未来的研究领域。