Joshi Trupti, Butchar Jonathan P, Tridandapani Susheela
Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute and Comprehensive Cancer Center, The Ohio State University, Room 405B HLRI, 473 W 12th Ave, OH 43210, Columbus, Ohio, USA.
Int J Hematol. 2006 Oct;84(3):210-216. doi: 10.1532/IJH97.06140. Epub 2018 Jan 16.
Fcγ receptors are among the best-studied phagocytic receptors. The key features of Fcγ receptor-mediated phagocytosis include phagocytic cup formation by extensive actin cytoskeletal rearrangements, particle engulfment, and the release of proinflammatory mediators such as cytokines and reactive oxygen species. These events are elegantly regulated by the simultaneous engagement of activating and inhibitory Fcγ receptors and by intracellular signaling molecules. Extensive studies in the past several years have defined the molecular mechanisms of the phagocytic process. The purpose of this review is to revisit some of the well-established signaling pathways as well as to summarize the new findings in this field.
Fcγ受体是研究最为深入的吞噬受体之一。Fcγ受体介导的吞噬作用的关键特征包括通过广泛的肌动蛋白细胞骨架重排形成吞噬杯、颗粒吞噬以及释放细胞因子和活性氧等促炎介质。这些事件通过激活型和抑制型Fcγ受体以及细胞内信号分子的同时作用而得到精细调节。过去几年的广泛研究已经明确了吞噬过程的分子机制。本综述的目的是回顾一些已确立的信号通路，并总结该领域的新发现。
