GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Mov Disord. 2010 Mar 15;25(4):481-5. doi: 10.1002/mds.22920.
Although motor features have been the defining element of essential tremor (ET), lower neurocognitive test scores are increasingly being recognized. However, the clinical correlates, if any, of these lower test scores remain largely unexplored. The aim of this study was to determine whether cognitive test scores in ET have any functional correlates. The Modified Mini Mental Status Examination (MMSE), Katz Activities of Daily Living (ADL) scale and Lawton Instrumental (I) ADL scale were administered to 95 cases. The Katz ADL score (rho = 0.26, P = 0.01) and Lawton IADL score (rho = 0.32, P = 0.001) were correlated with MMSE scores, such that poorer cognitive performance indicated greater dysfunction. Furthermore, cognitive test scores were a better predictor of functional disability than was tremor severity. Poorer cognitive performance in ET was associated with greater functional deficit. Cognition should enter the clinical dialog with ET patients as an issue of clinical significance.
虽然运动特征一直是原发性震颤（ET）的决定性因素，但越来越多的人认识到较低的神经认知测试分数。然而，这些较低测试分数的临床相关性（如果有的话）在很大程度上仍未得到探索。本研究旨在确定 ET 中的认知测试分数是否具有任何功能相关性。对 95 例患者进行了改良的简易精神状态检查（MMSE）、Katz 日常生活活动（ADL）量表和 Lawton 工具性（I）ADL 量表评估。Katz ADL 评分（rho=0.26，P=0.01）和 Lawton IADL 评分（rho=0.32，P=0.001）与 MMSE 评分相关，表明认知表现越差，功能障碍越严重。此外，认知测试分数比震颤严重程度更能预测功能障碍。ET 中较差的认知表现与更大的功能缺陷相关。认知障碍应该成为 ET 患者临床对话中的一个重要问题。
