a Pharmacology Department, Assiut University, Faculty of Medicine , Assiut , Egypt.
b Pathology Department, Assiut University, Faculty of Medicine , Assiut , Egypt.
Clin Exp Hypertens. 2018;40(8):703-714. doi: 10.1080/10641963.2018.1425421. Epub 2018 Jan 19.
Ginkgo biloba leaves extract has been widely used worldwide to protect against oxidative stress-induced cell damage and improves blood circulation.
The potential protective role of the standardized leaf extract of Ginkgo biloba (EGb761) on hypertension-induced renal injury was investigated in rats. Hypertension was induced in rats by L-NAME.
Repeated treatment with EGb761 produced progressive reductions in the systolic, diastolic and mean arterial blood pressure. Also, EGb761 increased the progressive reductions in blood pressure induced by losartan. Hypertension-induced marked elevation of renal malondialdehyde (MDA) and nitrite levels and reduction of reduced glutathione (GSH) level were inhibited by EGb761. In addition, hypertension-induced increases in tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β)) levels in renal tissues were inhibited by EGb761. Also, treatment with EGb761 inhibited hypertension-induced decrease in endothelial nitric oxide synthase (eNOS) protein expression and increase in the protein expressions of inducible NO synthase (iNOS), TNF-α, IL-6 and IL-1B in the kidney tissues. EGb761 enhanced losartan effects on renal tissues oxidative stress, nitrite, and inflammatory markers levels and on protein expressions of eNOS, iNOS, TNF-α, IL-6 and IL-1B. effects.
These results indicate that EGb761 has the ability to protect against hypertension-induced renal injury.
银杏叶提取物已在全球范围内广泛用于防止氧化应激引起的细胞损伤并改善血液循环。
研究了标准化银杏叶提取物（EGb761）对高血压引起的肾损伤的潜在保护作用。通过 L-NAME 在大鼠中诱导高血压。
银杏叶提取物（EGb761）的重复治疗可逐渐降低收缩压、舒张压和平均动脉压。此外，银杏叶提取物（EGb761）增加了氯沙坦诱导的血压逐渐降低。银杏叶提取物（EGb761）抑制了高血压引起的肾丙二醛（MDA）和亚硝酸盐水平升高和还原型谷胱甘肽（GSH）水平降低。此外，银杏叶提取物（EGb761）抑制了高血压引起的肾组织肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和白细胞介素-1β（IL-1β）水平升高。此外，银杏叶提取物（EGb761）抑制了高血压引起的内皮型一氧化氮合酶（eNOS）蛋白表达降低和诱导型一氧化氮合酶（iNOS）、TNF-α、IL-6 和 IL-1B 蛋白表达增加。银杏叶提取物（EGb761）增强了氯沙坦对肾组织氧化应激、亚硝酸盐和炎症标志物水平以及 eNOS、iNOS、TNF-α、IL-6 和 IL-1B 蛋白表达的影响。
这些结果表明，银杏叶提取物（EGb761）具有防止高血压引起的肾损伤的能力。
