Bürgisser E, Raine A E, Erne P, Kamber B, Bühler F R
Biochem Biophys Res Commun. 1985 Dec 31;133(3):1201-9. doi: 10.1016/0006-291x(85)91264-1.
The presence of high affinity receptors for atrial natriuretic peptide in bovine adrenal cortex has enabled the development of a sensitive, specific and rapid radioreceptor assay for this peptide in human plasma. In 18 normal subjects, venous plasma atrial natriuretic peptide concentration ranged from 6 to 65 pM. This plasma concentration was two-fold higher in right atrium as compared to venous blood in 12 patients investigated by cardiac catheterisation, confirming that the right atrium is the site of release of atrial natriuretic peptide into circulation. There was a further step up in plasma atrial natriuretic peptide concentration between pulmonary arterial and aortic plasma. This finding indicates that released hormone in man may undergo further activation in the lungs, or that there may be direct release from the left atrium.
牛肾上腺皮质中存在心房利钠肽的高亲和力受体，这使得能够开发出一种用于检测人血浆中该肽的灵敏、特异且快速的放射受体测定法。在18名正常受试者中，静脉血浆心房利钠肽浓度范围为6至65皮摩尔/升。在12名通过心导管检查的患者中，右心房的这种血浆浓度比静脉血高出两倍，证实右心房是心房利钠肽释放到循环中的部位。肺动脉血浆和主动脉血浆之间的血浆心房利钠肽浓度进一步升高。这一发现表明，人类释放的激素可能在肺部进一步激活，或者可能有来自左心房的直接释放。
