充血性心力衰竭治疗对血浆心钠素浓度的影响：一项纵向研究。
The effect of treatment of congestive heart failure on plasma atrial natriuretic peptide concentration: a longitudinal study.
作者信息
Anderson J V, Woodruff P W, Bloom S R
机构信息
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
出版信息
Br Heart J. 1988 Feb;59(2):207-11. doi: 10.1136/hrt.59.2.207.
Eleven patients with acute congestive heart failure were studied during treatment with a loop diuretic. Plasma concentrations of atrial natriuretic peptide were considerably increased before treatment and with successful treatment returned progressively towards normal values. There was a statistically significant correlation between plasma atrial natriuretic peptide concentration and both jugular venous pressure and change of body weight. These results support the hypothesis that atrial distension is an important stimulus to atrial natriuretic peptide release. Furthermore, the close relation between plasma concentrations of atrial natriuretic peptide and clinical improvement in these patients suggests that measurement of plasma atrial natriuretic peptide concentration could provide a clinically useful and non-invasive method of monitoring the response to treatment.
对11例急性充血性心力衰竭患者在使用袢利尿剂治疗期间进行了研究。治疗前血浆心房利钠肽浓度显著升高，随着治疗成功，其浓度逐渐恢复至正常水平。血浆心房利钠肽浓度与颈静脉压及体重变化之间存在统计学上的显著相关性。这些结果支持心房扩张是心房利钠肽释放的重要刺激因素这一假说。此外，这些患者血浆心房利钠肽浓度与临床改善之间的密切关系表明，测量血浆心房利钠肽浓度可为监测治疗反应提供一种临床有用且非侵入性的方法。
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