用于扫描质子笔形束（PBS）剂量测定的GAFCHROMIC EBT3薄膜校准

CALIBRATION OF GAFCHROMIC EBT3 FILM FOR DOSIMETRY OF SCANNING PROTON PENCIL BEAM (PBS).

作者信息

Krzempek D, Mianowska G, Bassler N, Stolarczyk L, Kopec R, Sas-Korczynska B, Olko P

机构信息

Institute of Nuclear Physics Polish Academy of Sciences, Krakow, Poland.

AGH University of Science and Technology, Krakow, Poland.

出版信息

Radiat Prot Dosimetry. 2018 Aug 1;180(1-4):324-328. doi: 10.1093/rpd/ncx304.

DOI:10.1093/rpd/ncx304

PMID:29351653

Abstract

Gafchromic EBT3 films are applied in proton radiotherapy for 2D dose mapping because they demonstrate spatial resolution well below 1 mm. However, the film response must be corrected in order to reach the accuracy of dose measurements required for the clinical use. The in-house developed AnalyseGafchromic software allows to analyze and correct the measured response using triple channel dose calibration, statistical scan-to-scan fluctuations as well as experimentally determined dose and LET dependence. Finally, the optimized protocol for evaluation of response of Gafchromic EBT3 films was applied to determine 30 × 40 cm2 dose profiles of the scanning therapy unit at the Cyclotron Centre Bronowice, CCB in Krakow, Poland.

摘要

Gafchromic EBT3薄膜因其展现出远低于1毫米的空间分辨率而应用于质子放射治疗的二维剂量映射。然而，为达到临床使用所需剂量测量的精度，必须对薄膜响应进行校正。内部开发的AnalyseGafchromic软件允许使用三通道剂量校准、统计扫描间波动以及实验确定的剂量和传能线密度依赖性来分析和校正测量响应。最后，将优化的Gafchromic EBT3薄膜响应评估方案应用于确定波兰克拉科夫布罗诺维采回旋加速器中心（CCB）扫描治疗单元的30×40平方厘米剂量分布。