Langeland Halvor, Bergum Daniel, Løberg Magnus, Bjørnstad Knut, Damås Jan Kristian, Mollnes Tom Eirik, Skjærvold Nils-Kristian, Klepstad Pål
Department of Anesthesiology and Intensive Care Medicine, St. Olav's University Hospital, Trondheim, Norway.
Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, The Norwegian University of Science and Technology, Trondheim, Norway.
JMIR Res Protoc. 2018 Jan 19;7(1):e17. doi: 10.2196/resprot.8558.
The post cardiac arrest syndrome (PCAS) is responsible for the majority of in-hospital deaths following cardiac arrest (CA). The major elements of PCAS are anoxic brain injury and circulatory failure.
This study aimed to investigate the clinical characteristics of circulatory failure and inflammatory responses after out-of-hospital cardiac arrest (OHCA) and to identify patterns of circulatory and inflammatory responses, which may predict circulatory deterioration in PCAS.
This study is a single-center cohort study of 50 patients who receive intensive care after OHCA. The patients are followed for 5 days where detailed information from circulatory variables, including measurements by pulmonary artery catheters (PACs), is obtained in high resolution. Blood samples for inflammatory and endothelial biomarkers are taken at inclusion and thereafter daily. Every 10 min, the patients will be assessed and categorized in one of three circulatory categories. These categories are based on mean arterial pressure; heart rate; serum lactate concentrations; superior vena cava oxygen saturation; and need for fluid, vasoactive medications, and other interventions. We will analyze predictors of circulatory failure and their relation to inflammatory biomarkers.
Patient inclusion started in January 2016.
This study will obtain advanced hemodynamic data with high resolution during the acute phase of PCAS and will analyze the details in circulatory state transitions related to circulatory failure. We aim to identify early predictors of circulatory deterioration and favorable outcome after CA.
ClinicalTrials.gov: NCT02648061; https://clinicaltrials.gov/ct2/show/NCT02648061 (Archived by WebCite at http://www.webcitation.org/6wVASuOla).
心脏骤停后综合征（PCAS）是心脏骤停（CA）后院内死亡的主要原因。PCAS的主要因素是缺氧性脑损伤和循环衰竭。
本研究旨在调查院外心脏骤停（OHCA）后循环衰竭和炎症反应的临床特征，并确定循环和炎症反应模式，这些模式可能预测PCAS中的循环恶化。
本研究是一项对50例OHCA后接受重症监护的患者进行的单中心队列研究。对患者进行为期5天的随访，以高分辨率获取来自循环变量的详细信息，包括通过肺动脉导管（PAC）测量的数据。在纳入时及之后每天采集用于检测炎症和内皮生物标志物的血样。每隔10分钟对患者进行评估，并将其归类为三种循环类别之一。这些类别基于平均动脉压、心率、血清乳酸浓度、上腔静脉血氧饱和度以及对液体、血管活性药物和其他干预措施的需求。我们将分析循环衰竭的预测因素及其与炎症生物标志物的关系。
患者纳入于2016年1月开始。
本研究将在PCAS急性期获得高分辨率的先进血流动力学数据，并将分析与循环衰竭相关的循环状态转变的细节。我们旨在确定CA后循环恶化和良好预后的早期预测因素。
ClinicalTrials.gov：NCT02648061；https://clinicaltrials.gov/ct2/show/NCT02648061（由WebCite存档于http://www.webcitation.org/6wVASuOla）。
