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Specificity of esterases and structure of prodrug esters. II. Hydrolytic regeneration behavior of 5-fluoro-2'-deoxyuridine (FUdR) from 3',5'-diesters of FUdR with rat tissue homogenates and plasma in relation to their antitumor activity.

作者信息

Kawaguchi T, Saito M, Suzuki Y, Nambu N, Nagai T

出版信息

Chem Pharm Bull (Tokyo). 1985 Apr;33(4):1652-9. doi: 10.1248/cpb.33.1652.

DOI:10.1248/cpb.33.1652
PMID:2931191
Abstract
摘要

相似文献

1
Specificity of esterases and structure of prodrug esters. II. Hydrolytic regeneration behavior of 5-fluoro-2'-deoxyuridine (FUdR) from 3',5'-diesters of FUdR with rat tissue homogenates and plasma in relation to their antitumor activity.酯酶的特异性与前药酯的结构。II. 5-氟-2'-脱氧尿苷（FUdR）3',5'-二酯在大鼠组织匀浆和血浆中的水解再生行为及其与抗肿瘤活性的关系
Chem Pharm Bull (Tokyo). 1985 Apr;33(4):1652-9. doi: 10.1248/cpb.33.1652.
2
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Activity of esterase in the hydrolysis of 3',5'-diesters of 5-fluoro-2'-deoxyuridine in relation to the structure of the diester prodrugs.酯酶在5-氟-2'-脱氧尿苷3',5'-二酯水解中的活性与二酯前药结构的关系
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Antitumor activity of 3',5'-diesters of 5-fluoro-2'-deoxyuridine against murine leukemia L1210 cells.
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In-vitro stability and cytostatic activity of liposomal formulations of 5-fluoro-2'-deoxyuridine and its diacylated derivatives.5-氟-2'-脱氧尿苷及其二酰化衍生物脂质体制剂的体外稳定性和细胞抑制活性
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In vivo distribution and antitumour activity of liposomal 3',5'-O-dipalmitoyl-5-fluoro-2'-deoxyuridine.脂质体3',5'-O-二棕榈酰-5-氟-2'-脱氧尿苷的体内分布及抗肿瘤活性
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3',5'-Diesters of 5-fluoro-2'-deoxyuridine and thymidine: hydrolysis by esterases in human, mouse, and insect tissue.5-氟-2'-脱氧尿苷和胸苷的3',5'-二酯：在人、小鼠和昆虫组织中被酯酶水解
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