5-氟-2'-脱氧尿苷（FUdR）酯的非酶促水解和酶促水解
Nonenzymatic and enzymatic hydrolysis of 5-fluoro-2'-deoxyuridine (FUdR) esters.
作者信息
Kawaguchi T, Fukushima S, Hayashi Y, Nakano M
机构信息
Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
出版信息
Pharm Res. 1988 Nov;5(11):741-4. doi: 10.1023/a:1015972214747.
PMID:2977648
Abstract
The chemical and enzymatic reactivity of 5-fluoro-2'-deoxyuridine prodrugs esterified at the 3' and 5' positions with several acyl groups has been investigated. The enzymatic reactivity was affected by the acyl structure, the site of esterification, and the number of esters in the prodrug molecule.
摘要
对在3'和5'位被几种酰基酯化的5-氟-2'-脱氧尿苷前药的化学和酶促反应活性进行了研究。酶促反应活性受酰基结构、酯化位点以及前药分子中酯的数量影响。
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