• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

5-氟-2'-脱氧尿苷（FUdR）酯的非酶促水解和酶促水解

Nonenzymatic and enzymatic hydrolysis of 5-fluoro-2'-deoxyuridine (FUdR) esters.

作者信息

Kawaguchi T, Fukushima S, Hayashi Y, Nakano M

机构信息

Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.

出版信息

Pharm Res. 1988 Nov;5(11):741-4. doi: 10.1023/a:1015972214747.

DOI:10.1023/a:1015972214747
PMID:2977648
Abstract

The chemical and enzymatic reactivity of 5-fluoro-2'-deoxyuridine prodrugs esterified at the 3' and 5' positions with several acyl groups has been investigated. The enzymatic reactivity was affected by the acyl structure, the site of esterification, and the number of esters in the prodrug molecule.

摘要

对在3'和5'位被几种酰基酯化的5-氟-2'-脱氧尿苷前药的化学和酶促反应活性进行了研究。酶促反应活性受酰基结构、酯化位点以及前药分子中酯的数量影响。

相似文献

1
Nonenzymatic and enzymatic hydrolysis of 5-fluoro-2'-deoxyuridine (FUdR) esters.5-氟-2'-脱氧尿苷（FUdR）酯的非酶促水解和酶促水解
Pharm Res. 1988 Nov;5(11):741-4. doi: 10.1023/a:1015972214747.
2
Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis.氟尿苷的氨基酸酯前药：合成以及结构、立体化学和酯化位点对水解速率的影响
Pharm Res. 2003 Sep;20(9):1381-8. doi: 10.1023/a:1025745824632.
3
Activity of esterase in the hydrolysis of 3',5'-diesters of 5-fluoro-2'-deoxyuridine in relation to the structure of the diester prodrugs.酯酶在5-氟-2'-脱氧尿苷3',5'-二酯水解中的活性与二酯前药结构的关系
Chem Pharm Bull (Tokyo). 1985 Jan;33(1):301-7. doi: 10.1248/cpb.33.301.
4
Controlled release of 5-fluoro-2'-deoxyuridine by the combination of prodrug and polymer matrix.通过前药与聚合物基质的组合实现5-氟-2'-脱氧尿苷的控释。
Chem Pharm Bull (Tokyo). 1991 Feb;39(2):458-64. doi: 10.1248/cpb.39.458.
5
Specificity of esterases and structure of prodrug esters. II. Hydrolytic regeneration behavior of 5-fluoro-2'-deoxyuridine (FUdR) from 3',5'-diesters of FUdR with rat tissue homogenates and plasma in relation to their antitumor activity.酯酶的特异性与前药酯的结构。II. 5-氟-2'-脱氧尿苷（FUdR）3',5'-二酯在大鼠组织匀浆和血浆中的水解再生行为及其与抗肿瘤活性的关系
Chem Pharm Bull (Tokyo). 1985 Apr;33(4):1652-9. doi: 10.1248/cpb.33.1652.
6
Controlled release of 3',5'-diester prodrugs of 5-fluoro-2'-deoxyuridine from poly-L-lactic acid microspheres.5-氟-2'-脱氧尿苷的3',5'-二酯前药从聚-L-乳酸微球中的控释。
J Pharm Sci. 1990 Nov;79(11):985-7. doi: 10.1002/jps.2600791108.
7
Specificity of esterases and structures of prodrug esters. III. Activity of rat tissue homogenates, rat plasma and porcine liver esterase for the hydrolysis of 3',5'-bis-dicarboxylic acid hemiesters of 5-fluoro-2'-deoxyuridine.酯酶的特异性及前药酯的结构。III. 大鼠组织匀浆、大鼠血浆和猪肝酯酶对5-氟-2'-脱氧尿苷3',5'-双二羧酸半酯的水解活性。
Chem Pharm Bull (Tokyo). 1985 Jul;33(7):2956-61. doi: 10.1248/cpb.33.2956.
8
The antitumour effect of lipophilic derivatives of 5-fluoro-2'-deoxyuridine incorporated into liposomes.掺入脂质体的5-氟-2'-脱氧尿苷亲脂性衍生物的抗肿瘤作用。
J Microencapsul. 1988 Jan-Mar;5(1):1-11. doi: 10.3109/02652048809036717.
9
Potentiation of the antitumor effect of 5-fluoro-2'-deoxyuridine esters in combination with acyclothymidine esters on L1210 in mice via oral administration.5-氟-2'-脱氧尿苷酯与阿昔洛韦酯联合经口服给药对小鼠L1210的抗肿瘤作用增强。
J Pharm Sci. 1988 Nov;77(11):939-43. doi: 10.1002/jps.2600771108.
10
5-Fluorouracil derivatives. III. A simple method to prepare 5-fluoro-2'-deoxyuridine derivatives.5-氟尿嘧啶衍生物。III. 制备5-氟-2'-脱氧尿苷衍生物的一种简单方法。
Nucleic Acids Symp Ser. 1983(12):9-12.

引用本文的文献

1
Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis.氟尿苷的氨基酸酯前药：合成以及结构、立体化学和酯化位点对水解速率的影响
Pharm Res. 2003 Sep;20(9):1381-8. doi: 10.1023/a:1025745824632.

本文引用的文献

1
A pharmacokinetic analysis program (multi) for microcomputer.一种用于微型计算机的药代动力学分析程序（多功能）。
J Pharmacobiodyn. 1981 Nov;4(11):879-85. doi: 10.1248/bpb1978.4.879.
2
Antitumor activity of 3',5'-diesters of 5-fluoro-2'-deoxyuridine against murine leukemia L1210 cells.
Cancer Chemother Pharmacol. 1981;6(1):19-23. doi: 10.1007/BF00253005.
3
3',5'-Diesters of 5-fluoro-2'-deoxyuridine and thymidine: hydrolysis by esterases in human, mouse, and insect tissue.5-氟-2'-脱氧尿苷和胸苷的3',5'-二酯：在人、小鼠和昆虫组织中被酯酶水解
Biochem Pharmacol. 1966 May;15(5):627-44. doi: 10.1016/0006-2952(66)90030-x.
4
3',5'-diesters of 5-fluoro-2'-deoxyuridine: synthesis and biological activity.
Biochem Pharmacol. 1965 Nov;14(11):1605-19. doi: 10.1016/0006-2952(65)90015-8.
5
Activity of esterase in the hydrolysis of 3',5'-diesters of 5-fluoro-2'-deoxyuridine in relation to the structure of the diester prodrugs.酯酶在5-氟-2'-脱氧尿苷3',5'-二酯水解中的活性与二酯前药结构的关系
Chem Pharm Bull (Tokyo). 1985 Jan;33(1):301-7. doi: 10.1248/cpb.33.301.
6
Selective anticancer effects of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine, a lipophilic prodrug of 5-fluoro-2'-deoxyuridine, dissolved in an oily lymphographic agent on hepatic cancer of rabbits bearing VX-2 tumor.
Cancer Res. 1987 Apr 1;47(7):1930-4.
7
Specificity of esterases and structure of prodrug esters. II. Hydrolytic regeneration behavior of 5-fluoro-2'-deoxyuridine (FUdR) from 3',5'-diesters of FUdR with rat tissue homogenates and plasma in relation to their antitumor activity.酯酶的特异性与前药酯的结构。II. 5-氟-2'-脱氧尿苷（FUdR）3',5'-二酯在大鼠组织匀浆和血浆中的水解再生行为及其与抗肿瘤活性的关系
Chem Pharm Bull (Tokyo). 1985 Apr;33(4):1652-9. doi: 10.1248/cpb.33.1652.